Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 781088..781767 Replicon chromosome
Accession NZ_CP051659
Organism Escherichia coli strain 1162C

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag HH202_RS03760 Protein ID WP_000057523.1
Coordinates 781088..781390 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag HH202_RS03765 Protein ID WP_000806442.1
Coordinates 781426..781767 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH202_RS03735 (776464) 776464..778116 + 1653 WP_000771748.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
HH202_RS03740 (778154) 778154..778657 - 504 WP_000667000.1 hypothetical protein -
HH202_RS03745 (778654) 778654..779454 - 801 WP_000439798.1 hypothetical protein -
HH202_RS03750 (779478) 779478..779957 - 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
HH202_RS03755 (780161) 780161..780955 - 795 WP_000365147.1 TraB/GumN family protein -
HH202_RS03760 (781088) 781088..781390 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HH202_RS03765 (781426) 781426..781767 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
HH202_RS03770 (781825) 781825..784329 - 2505 WP_000083947.1 copper-exporting P-type ATPase CopA -
HH202_RS03775 (784591) 784591..785523 + 933 WP_000883041.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T154645 WP_000057523.1 NZ_CP051659:781088-781390 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

>T154645 NZ_CP068195:877787-878080 [Acinetobacter johnsonii]
ATGACTTATAAGCTTTTACGTCACAAAGACTTTAAAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGGGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT154645 WP_000806442.1 NZ_CP051659:781426-781767 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp

>AT154645 NZ_CP068195:877552-877797 [Acinetobacter johnsonii]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCCTATTCCATCCTTAAAGAACAAGGTATTGCACC
TACAGATTTCTTTACTAGTATTCTTGAATATGTTGCTACGACTGGGAAACTACCTGTCAAAAAAGCTCTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References