154598

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1551559..1552071 Replicon chromosome
Accession NZ_CP051650
Organism Streptococcus pneumoniae strain B1900

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag HG605_RS07820 Protein ID WP_000924721.1
Coordinates 1551559..1551813 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag HG605_RS07825 Protein ID WP_000388572.1
Coordinates 1551817..1552071 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG605_RS07805 (HG605_07910) 1548660..1548974 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
HG605_RS07810 (HG605_07915) 1548999..1549625 - 627 WP_000775037.1 guanylate kinase -
HG605_RS07815 (HG605_07920) 1549755..1551368 - 1614 WP_000404940.1 ribonuclease Y -
HG605_RS07820 (HG605_07925) 1551559..1551813 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
HG605_RS07825 (HG605_07930) 1551817..1552071 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HG605_RS07830 (HG605_07935) 1552309..1553406 - 1098 WP_061371237.1 nucleotidyltransferase -
HG605_RS07835 (HG605_07940) 1553416..1554162 - 747 WP_223616910.1 class I SAM-dependent methyltransferase -
HG605_RS07840 (HG605_07945) 1554265..1554618 - 354 WP_001003001.1 ribosome silencing factor -
HG605_RS07845 (HG605_07950) 1554631..1555131 - 501 WP_050154899.1 cysteine hydrolase family protein -
HG605_RS07850 (HG605_07955) 1555132..1555725 - 594 WP_044789081.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
HG605_RS07855 (HG605_07960) 1555725..1556354 - 630 WP_050154901.1 nicotinate-nucleotide adenylyltransferase -
HG605_RS07860 (HG605_07965) 1556406..1556717 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T154598 WP_000924721.1 NZ_CP051650:c1551813-1551559 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T154598 NZ_CP068155:902387-902605 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT154598 WP_000388572.1 NZ_CP051650:c1552071-1551817 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT154598 NZ_CP068155:901987-902361 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References