Detailed information of TA system TA154579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1605308..1605977
• Replicon: chromosome
• Accession: NZ_CP051641
• Organism: Avibacterium paragallinarum strain ADL-AP02

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A380X0Q1
• Locus tag: HHJ57_RS07490
• Protein ID: WP_017807010.1
• Coordinates: 1605612..1605977 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HHJ57_RS07485
• Protein ID: WP_017807009.1
• Coordinates: 1605308..1605610 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ57_RS07470	1601935..1602810	-	876	WP_017807006.1	VirK/YbjX family protein	-
HHJ57_RS07475	1602926..1604266	-	1341	WP_017807007.1	argininosuccinate synthase	-
HHJ57_RS07480	1604357..1605196	-	840	WP_017807008.1	SDR family oxidoreductase	-
HHJ57_RS07485	1605308..1605610	-	303	WP_017807009.1	XRE family transcriptional regulator	Antitoxin
HHJ57_RS07490	1605612..1605977	-	366	WP_017807010.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ57_RS07495	1606227..1607087	-	861	WP_035686936.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HHJ57_RS07500	1607269..1608858	+	1590	WP_035686939.1	peptide chain release factor 3	-
HHJ57_RS07505	1609183..1610028	-	846	WP_017807013.1	elongation factor Ts	-
HHJ57_RS07510	1610160..1610888	-	729	WP_017807014.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14098.33 Da
• Isoelectric Point: 4.9436

>T154579 WP_017807010.1 NZ_CP051641:c1605977-1605612 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Nucleotide

• Length: 366 bp

>T154579 NZ_CP068151:c543570-543220 [Pseudomonas fluorescens]
ATGGATGCTCTATTTATCGAACTGCCGGCATTCGAGCGGTATCGCAAAGACTATCTGAGTGACGAGCTTTTCCAGGGTTT
TCAACAGGAGTTAATGAAAAACCCCGAAGCAGGAGACGTGATCGAAGGGACGGGCGGGTTGAGGAAGGTTCGCTTCATCG
ATGAACGACGAAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTATTACTGGTGGTCAGGCGGTACGCAATTCTGGTTA
TTCACCTTGTACGGCAAACACGAACAAAACGACCTGGCACCGCAACACAAGAAAGCCCTTAAACACATGCTGGTCAGGGA
AATCAAAGCGAGAATGCACAATGAAACGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11238.21 Da
• Isoelectric Point: 9.5655

>AT154579 WP_017807009.1 NZ_CP051641:c1605610-1605308 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Nucleotide

• Length: 303 bp

>AT154579 NZ_CP068151:c543230-542916 [Pseudomonas fluorescens]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGCTTCGACGCTTTGGCCGATGAACGCCAGGGTAAAATCACCCTGCG
CAACCACAAAGTGCACCTCAACAAGCTGGCGCCGCTTACCGCAGACGAGGTGATCGCTGTGCGCCAGCAACTCAACCTCT
CCCGGTCGGTATTCGCCATGTATCTGCGTACCAACACCCGCACCCTGGAGAACTGGGAACAAGGCCGGGCCAAACCCAAC
GCCCAGGCCGTCACCCTGATCCGCCTGGTGGCGCGCTTTCCGGAAACCGTGGCGCAACTGGCCGCACTGGGCTGA

Structures

Toxin

• AlphaFold DB: A0A380X0Q1