Detailed information of TA system TA154571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1605210..1605879
• Replicon: chromosome
• Accession: NZ_CP051640
• Organism: Avibacterium paragallinarum strain ADL-AP07

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A380X0Q1
• Locus tag: HHJ58_RS07495
• Protein ID: WP_017807010.1
• Coordinates: 1605514..1605879 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HHJ58_RS07490
• Protein ID: WP_017807009.1
• Coordinates: 1605210..1605512 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ58_RS07475	1601837..1602712	-	876	WP_017807006.1	VirK/YbjX family protein	-
HHJ58_RS07480	1602828..1604168	-	1341	WP_017807007.1	argininosuccinate synthase	-
HHJ58_RS07485	1604259..1605098	-	840	WP_017807008.1	SDR family oxidoreductase	-
HHJ58_RS07490	1605210..1605512	-	303	WP_017807009.1	XRE family transcriptional regulator	Antitoxin
HHJ58_RS07495	1605514..1605879	-	366	WP_017807010.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ58_RS07500	1606129..1606989	-	861	WP_035686936.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HHJ58_RS07505	1607171..1608760	+	1590	WP_035686939.1	peptide chain release factor 3	-
HHJ58_RS07510	1609085..1609930	-	846	WP_017807013.1	elongation factor Ts	-
HHJ58_RS07515	1610062..1610790	-	729	WP_017807014.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14098.33 Da
• Isoelectric Point: 4.9436

>T154571 WP_017807010.1 NZ_CP051640:c1605879-1605514 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Nucleotide

• Length: 366 bp

>T154571 NZ_CP068148:1217871-1218254 [Serratia liquefaciens]
ATGAAATGGATCAGCGCTCAGGAGGTGGTTGCATTTCACGATCGCTTGCTCGCAGCTCTGCCAGGGGTTCCAGGTATGCC
GGAGCCAGGTCGGGCTGAGGCCATTATCTATCGCGTACAGAACCAGCTTTACTATGAAGGTGTTGAGGATATTCATGAGC
TTGCGGCTATGTACCTTATCGCCATAGCTCGCGGCCATATCTTTAATGATGGCAATAAACGAACAGCCTTTTTTGTGACG
ATGGCGTTTTTAAACCGCAACGGTATTCAGATCCGTGATGAAGGTAACGAACTGGAAGAATTAACGGTTTCCGCTGCAAC
TGGTGCCATCAGTACCGTAGAGATTTCTGCTGTTCTTCGCCAACTTTCCAATGCTTCCCGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11238.21 Da
• Isoelectric Point: 9.5655

>AT154571 WP_017807009.1 NZ_CP051640:c1605512-1605210 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Nucleotide

• Length: 303 bp

>AT154571 NZ_CP068148:1217653-1217874 [Serratia liquefaciens]
ATGCGAACTTACACCACATCTCAGGCGCGGCAGAATATTGCCGAAGTCATGGAGGCCGCTACCGCTGGCGAGCCGGTAGA
AATAACCCGTCGCGATGGGTCAGCCGCTGTGCTTATCAGTCGTGATGATTTCAATGCATGGCAAGAGGCAAAGCTTGATA
CAGAGTTTGCCGAAATCATGGGGCGTCATGGGCGCACCATTAAGGCACTGGCTGATAGATGA

Structures

Toxin

• AlphaFold DB: A0A380X0Q1