Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1113918..1114587 Replicon chromosome
Accession NZ_CP051640
Organism Avibacterium paragallinarum strain ADL-AP07

Toxin (Protein)


Gene name higB Uniprot ID A0A0F5ET33
Locus tag HHJ58_RS05245 Protein ID WP_017806586.1
Coordinates 1114228..1114587 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0F5EZ21
Locus tag HHJ58_RS05240 Protein ID WP_017806585.1
Coordinates 1113918..1114226 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ58_RS05225 1109831..1110310 + 480 WP_017806582.1 leucine-responsive transcriptional regulator Lrp -
HHJ58_RS05230 1110312..1113164 + 2853 WP_035684736.1 DNA translocase FtsK -
HHJ58_RS05235 1113246..1113866 + 621 WP_035684733.1 outer membrane lipoprotein chaperone LolA -
HHJ58_RS05240 1113918..1114226 - 309 WP_017806585.1 helix-turn-helix transcriptional regulator Antitoxin
HHJ58_RS05245 1114228..1114587 - 360 WP_017806586.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ58_RS05250 1114775..1116124 + 1350 WP_035684730.1 replication-associated recombination protein A -
HHJ58_RS05255 1116198..1117487 + 1290 WP_035684727.1 serine--tRNA ligase -
HHJ58_RS05260 1117691..1118773 + 1083 WP_035684725.1 peptide chain release factor 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13935.24 Da        Isoelectric Point: 10.3916

>T154568 WP_017806586.1 NZ_CP051640:c1114587-1114228 [Avibacterium paragallinarum]
MVVKKKWEVIATARFKIWLKEQDEATRISVFNALNNLRFYGPQLSRPYVDTIKGSQYPNMKELRIQHKSKPLRAFFAFDP
LRQAIVLCAGNKSNNKQFYKQMITIADAEFTDYLATLEK

Download         Length: 360 bp

>T154568 NZ_CP068148:796166-796588 [Serratia liquefaciens]
GTGGCCCAGTGGCGATGTGATGTTCGTATTTCCTGGCGCACCCAGTTACTTTCGCTGTTGACGCATGGCGTTCTGATCCT
GCTGATCCTGATTTCACCCTGGCCTGAAGGCTACGGGCCAATCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTGAATGCA
TACGTAGCCAAAAACGCATTGCGTCGCGTCAGGGGGAGTTACGCCTGCTGGAGAACCAGCGTGTGGGCTGGCAAGGCCAG
GAATGGCAGTTGGCCAAGCAACCCTGGATGCTGCGCTTCGGTATTCTGCTGACGTTGCAACCGATGCAGGGGAAAAAGCG
TCGTCGCTTATGGTTGGCCTCCGACAGCATGGCCAAGGCCGAATGGCGACATTTGCGCCAACAGCTGTTGTATCCACCGG
CCAGTGATGATGAGGAACCCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11378.12 Da        Isoelectric Point: 4.3491

>AT154568 WP_017806585.1 NZ_CP051640:c1114226-1113918 [Avibacterium paragallinarum]
MTQYTTLDELIAQESPETQQCIKEMSEELILETGLAMIREQLALSQKELAQAIGVSQSAIAQIEQRGNDVKLSTLKRYIE
KMGGELSLTVKMPTGYSQIFPL

Download         Length: 309 bp

>AT154568 NZ_CP068148:795919-796185 [Serratia liquefaciens]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCTTGTCGCCGTGGCATGCGTGAGCTGGACATCTCGATCATGCCGTT
CTTCGAATATGAGTACGATCGGTTGAATGACACAGACAAAGCGCTGTTTATCCGCCTGCTTGAGAGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5ET33

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5EZ21

References