Detailed information of TA system TA154563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1604728..1605397
• Replicon: chromosome
• Accession: NZ_CP051639
• Organism: Avibacterium paragallinarum strain ADL-AP10

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A380X0Q1
• Locus tag: HHJ59_RS07505
• Protein ID: WP_017807010.1
• Coordinates: 1605032..1605397 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HHJ59_RS07500
• Protein ID: WP_017807009.1
• Coordinates: 1604728..1605030 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ59_RS07485	1601355..1602230	-	876	WP_017807006.1	VirK/YbjX family protein	-
HHJ59_RS07490	1602346..1603686	-	1341	WP_017807007.1	argininosuccinate synthase	-
HHJ59_RS07495	1603777..1604616	-	840	WP_017807008.1	SDR family oxidoreductase	-
HHJ59_RS07500	1604728..1605030	-	303	WP_017807009.1	XRE family transcriptional regulator	Antitoxin
HHJ59_RS07505	1605032..1605397	-	366	WP_017807010.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ59_RS07510	1605647..1606507	-	861	WP_035686936.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HHJ59_RS07515	1606689..1608278	+	1590	WP_035686939.1	peptide chain release factor 3	-
HHJ59_RS07520	1608603..1609448	-	846	WP_017807013.1	elongation factor Ts	-
HHJ59_RS07525	1609580..1610308	-	729	WP_017807014.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14098.33 Da
• Isoelectric Point: 4.9436

>T154563 WP_017807010.1 NZ_CP051639:c1605397-1605032 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Nucleotide

• Length: 366 bp

>T154563 NZ_CP068147:3640298-3640576 [Yersinia enterocolitica]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
AAATAAACTTAAAACTATTATGGCGCTGCTAATTGACGATAAATTACCCTTGCCTGTTATATACAAGGATCATCAATTAC
AAGGTAATTACAAAGGTTACAGGGATGCGCATATAGAGCCAGACTGGCTTATCATCTACAAGATTACTGATGATTTGCTT
CGCTTCGAAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11238.21 Da
• Isoelectric Point: 9.5655

>AT154563 WP_017807009.1 NZ_CP051639:c1605030-1604728 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Nucleotide

• Length: 303 bp

>AT154563 NZ_CP068147:3640031-3640291 [Yersinia enterocolitica]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGATGAAACCCTAAAAAATGAAGCCGCTGCTGTGCTTGCTGGCATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTCGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACCGCTAAAACTATTGCCAACAGCGAGAAAGGTGTCGATGTCCACAAAGCAAAGGATGCCGATGATCTG
TTTGATAAATTAGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A380X0Q1