154555

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1605024..1605693 Replicon chromosome
Accession NZ_CP051638
Organism Avibacterium paragallinarum strain ADL-AP15

Toxin (Protein)


Gene name higB Uniprot ID A0A380X0Q1
Locus tag HHJ60_RS07515 Protein ID WP_017807010.1
Coordinates 1605328..1605693 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HHJ60_RS07510 Protein ID WP_017807009.1
Coordinates 1605024..1605326 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ60_RS07495 1601651..1602526 - 876 WP_017807006.1 VirK/YbjX family protein -
HHJ60_RS07500 1602642..1603982 - 1341 WP_017807007.1 argininosuccinate synthase -
HHJ60_RS07505 1604073..1604912 - 840 WP_017807008.1 SDR family oxidoreductase -
HHJ60_RS07510 1605024..1605326 - 303 WP_017807009.1 XRE family transcriptional regulator Antitoxin
HHJ60_RS07515 1605328..1605693 - 366 WP_017807010.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ60_RS07520 1605943..1606803 - 861 WP_035686936.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HHJ60_RS07525 1606985..1608574 + 1590 WP_035686939.1 peptide chain release factor 3 -
HHJ60_RS07530 1608899..1609744 - 846 WP_017807013.1 elongation factor Ts -
HHJ60_RS07535 1609876..1610604 - 729 WP_017807014.1 30S ribosomal protein S2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14098.33 Da        Isoelectric Point: 4.9436

>T154555 WP_017807010.1 NZ_CP051638:c1605693-1605328 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Download         Length: 366 bp

>T154555 NZ_CP068147:1145679-1147007 [Yersinia enterocolitica]
ATGGCTCGTCGCATTCAACGGCTCAATATCTGGATGAATGGTCAGCACGTTGGCTATTGGGAAAAAAATCGAGGCGAAGA
ATCGCTGGTTTATGCCCAAGAATGGTTAGCAAACGAACAAGGCCGACCACTATCATTATCATTGCCTTTCACTGCCAATA
ATCAGGTTTATAGAGGCAATATTGTCCGGGACTATTTTGATAATTTATTACCCGATAGCGATGATATCCGGCGACGTCTG
GCAACTAAATACCACGCTGACAGCATTAACCCTTTCGATCTATTGTTTGAATTAGGAAGAGATTGTGTCGGTGCAATACA
ATTGCTAACTGATGATGCTCCTCCCTCTGATCTATTCTCAATTCAACAACAACCACTAACAGAAAGCGATGTGGCTCGCA
TTCTACGAAACTCATTATCTGACAATGCATTTGTGCGCCCTGAACACGATGAGGATCTCAGATTGTCTATCGCAGGGGCA
CAAGAAAAAACAGCTCTTTTGTTTCACGACAACCGATGGTGCCTCCCATTGGGCAGCACTCCCACCACCCATATCTTCAA
ACTTCCGTTGGGCTTAGTCGGCAATATGCAAGCTGATATGAGGACCTCGGTTGAAAATGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTACCGGTCGCCAGTTGTGAAATTGGCCAGTTTGAAGACCAAAAAGCATTGATTGTTGAACGTTTT
GACCGACGTTTATCGCGTGACAAGAGTTGGATCGTCAGATTACCGCAAGAAGATATGTGCCAGGCCACTGGGACTTCTCC
CTTAAAAAAATATCAAATGGATGGTGGCCCCAGTATTACCACCATAATGGAGATTTTGAGTGGTTCGGATAATGCCAGTG
AAGACAGAAACGTCTTCTTTAAAGCACAGATTATTTTCTGGTTATTGGCCGCAACTGATGGACATGCAAAAAACTTTAGC
ATTGCTCATCTCCCCGGGAGTCGTTATCACCTCACGCCACTTTATGACGTGTTATCAACCCATCCGATTATCGGCTCGGG
TCGTAATCAGATTGCGATTCAAAAATCCAAGTTAGCGATGGCGGTAAGAGGGAGTAAAAATTACTATTTGATTAACCAGA
TCCAACGCCGTCATTGGCGAAAACAGGCAGAATTTGTTGGACTAGGAGCGATTCAAGCTGACACTATTATCGATGAAATA
ATTGCCGCAACCCCACGGGTTATCACACAAGTACAAGCTCAACTTCCGGCTAATTTTCCTGCTGACTTAGCAGAGAAAAT
CCTTACTGGCCTTCATAAACAATGTGAAAAAATCTCGGCAATGCTTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11238.21 Da        Isoelectric Point: 9.5655

>AT154555 WP_017807009.1 NZ_CP051638:c1605326-1605024 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Download         Length: 303 bp

>AT154555 NZ_CP068147:1145378-1145677 [Yersinia enterocolitica]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCGACGTTGATTGGTTTTCGAAAAAATAAAGGGCTGACTCAGGC
CAGCCTGGCACAACTGTTAGGTATCACCCAGCAGTCCTATGCAAAGCTTGAAGCTGATCCCACCTCGGCCAGTGTTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTGATTCTCACTGAGAAAAAAAACGCCAGCGCGCATCCCAATAAA
ACCCACCAGCCAGAACAAAGCCAGACGATAGATTTACCGTCAAAACAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380X0Q1

Antitoxin

Source ID Structure

References