Detailed information of TA system TA154547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1604965..1605634
• Replicon: chromosome
• Accession: NZ_CP051637
• Organism: Avibacterium paragallinarum strain ADL-AP16

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A380X0Q1
• Locus tag: HHJ61_RS07495
• Protein ID: WP_017807010.1
• Coordinates: 1605269..1605634 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HHJ61_RS07490
• Protein ID: WP_017807009.1
• Coordinates: 1604965..1605267 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ61_RS07475	1601592..1602467	-	876	WP_017807006.1	VirK/YbjX family protein	-
HHJ61_RS07480	1602583..1603923	-	1341	WP_017807007.1	argininosuccinate synthase	-
HHJ61_RS07485	1604014..1604853	-	840	WP_017807008.1	SDR family oxidoreductase	-
HHJ61_RS07490	1604965..1605267	-	303	WP_017807009.1	XRE family transcriptional regulator	Antitoxin
HHJ61_RS07495	1605269..1605634	-	366	WP_017807010.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ61_RS07500	1605884..1606744	-	861	WP_035686936.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HHJ61_RS07505	1606926..1608515	+	1590	WP_035686939.1	peptide chain release factor 3	-
HHJ61_RS07510	1608840..1609685	-	846	WP_017807013.1	elongation factor Ts	-
HHJ61_RS07515	1609817..1610545	-	729	WP_017807014.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14098.33 Da
• Isoelectric Point: 4.9436

>T154547 WP_017807010.1 NZ_CP051637:c1605634-1605269 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Nucleotide

• Length: 366 bp

>T154547 NZ_CP068146:c2039146-2038778 [Yersinia enterocolitica]
ATGCAGACCTTACCTGTCACCTCGAAACGGGCGGCCTACGCTTGCCTATCACCCGTTATTGTCTGGCAATCCATGCTCAC
GTATCTGCTAGAGCAGCATTACGGCCTGGTGCTTAGCGACACCGAGTTCAGTGATGACGCCGTTATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGCTGAATTTCACGGTGGAGAAGTTTGACTTGGCTCGCACCGATCACCGAGGTTTC
TCCTGCCAGGAACAATCTCCCTTTATCACGTCTATCGATATTCTCCGCGCTCGTCGAGCCACCGGTCTGATGACCCGTAT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGAGGAAAGCAGGCATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11238.21 Da
• Isoelectric Point: 9.5655

>AT154547 WP_017807009.1 NZ_CP051637:c1605267-1604965 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Nucleotide

• Length: 303 bp

>AT154547 NZ_CP068146:c2039362-2039210 [Yersinia enterocolitica]
CTGGAACTGATGCTGCTTTCTGGTGAGCTCAATCCCCGTTATCAGCACTGCGTCACGTTGTATCGCAATGGCTTGATCTG
CGAAGCCGATAGCCTGGGATCACAGGGTTATGTGTATCTCGCCATTTATCCTACTCCCCAATCAATTGCATAA

Structures

Toxin

• AlphaFold DB: A0A380X0Q1