Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 628670..629339 Replicon chromosome
Accession NZ_CP051637
Organism Avibacterium paragallinarum strain ADL-AP16

Toxin (Protein)


Gene name higB Uniprot ID A0A0F5ET33
Locus tag HHJ61_RS03010 Protein ID WP_017806586.1
Coordinates 628670..629029 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0F5EZ21
Locus tag HHJ61_RS03015 Protein ID WP_017806585.1
Coordinates 629031..629339 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ61_RS02995 624484..625566 - 1083 WP_035684725.1 peptide chain release factor 1 -
HHJ61_RS03000 625770..627059 - 1290 WP_035684727.1 serine--tRNA ligase -
HHJ61_RS03005 627133..628482 - 1350 WP_035684730.1 replication-associated recombination protein A -
HHJ61_RS03010 628670..629029 + 360 WP_017806586.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ61_RS03015 629031..629339 + 309 WP_017806585.1 helix-turn-helix transcriptional regulator Antitoxin
HHJ61_RS03020 629391..630011 - 621 WP_035684733.1 outer membrane lipoprotein chaperone LolA -
HHJ61_RS03025 630093..632945 - 2853 WP_035684736.1 DNA translocase FtsK -
HHJ61_RS03030 632947..633426 - 480 WP_017806582.1 leucine-responsive transcriptional regulator Lrp -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13935.24 Da        Isoelectric Point: 10.3916

>T154543 WP_017806586.1 NZ_CP051637:628670-629029 [Avibacterium paragallinarum]
MVVKKKWEVIATARFKIWLKEQDEATRISVFNALNNLRFYGPQLSRPYVDTIKGSQYPNMKELRIQHKSKPLRAFFAFDP
LRQAIVLCAGNKSNNKQFYKQMITIADAEFTDYLATLEK

Download         Length: 360 bp

>T154543 NZ_CP068146:c1290940-1290653 [Yersinia enterocolitica]
ATGATTTATAAAGTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11378.12 Da        Isoelectric Point: 4.3491

>AT154543 WP_017806585.1 NZ_CP051637:629031-629339 [Avibacterium paragallinarum]
MTQYTTLDELIAQESPETQQCIKEMSEELILETGLAMIREQLALSQKELAQAIGVSQSAIAQIEQRGNDVKLSTLKRYIE
KMGGELSLTVKMPTGYSQIFPL

Download         Length: 309 bp

>AT154543 NZ_CP068146:c1291188-1290937 [Yersinia enterocolitica]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5ET33

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5EZ21

References