Detailed information of TA system TA154539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1605030..1605699
• Replicon: chromosome
• Accession: NZ_CP051636
• Organism: Avibacterium paragallinarum strain ADL-AP17

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A380X0Q1
• Locus tag: HHJ62_RS07490
• Protein ID: WP_017807010.1
• Coordinates: 1605334..1605699 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HHJ62_RS07485
• Protein ID: WP_017807009.1
• Coordinates: 1605030..1605332 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ62_RS07470	1601657..1602532	-	876	WP_017807006.1	VirK/YbjX family protein	-
HHJ62_RS07475	1602648..1603988	-	1341	WP_017807007.1	argininosuccinate synthase	-
HHJ62_RS07480	1604079..1604918	-	840	WP_017807008.1	SDR family oxidoreductase	-
HHJ62_RS07485	1605030..1605332	-	303	WP_017807009.1	XRE family transcriptional regulator	Antitoxin
HHJ62_RS07490	1605334..1605699	-	366	WP_017807010.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ62_RS07495	1605949..1606809	-	861	WP_035686936.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HHJ62_RS07500	1606991..1608580	+	1590	WP_035686939.1	peptide chain release factor 3	-
HHJ62_RS07505	1608905..1609750	-	846	WP_017807013.1	elongation factor Ts	-
HHJ62_RS07510	1609882..1610610	-	729	WP_017807014.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14098.33 Da
• Isoelectric Point: 4.9436

>T154539 WP_017807010.1 NZ_CP051636:c1605699-1605334 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Nucleotide

• Length: 366 bp

>T154539 NZ_CP068145:c2887786-2887433 [Morganella morganii]
GTGTGGAAGATAGTCACAACAGATAATTTTACAGTGTGGTTTGCTGAGCAGGATGACGGAGATCGCGCAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGCGGGGACCCGGCTTACCAAGGCCGTATGCGGATACTGTAAAAGGTTCCCGGTATACGA
ATATGAAAGAGCTTCGTATACAGAGCAGGGGACAACCGATACGGGCATTTTTTGCATTCGACCCTGAGAGAAGAGGCGTC
TTGCTGTGCGCGGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATCCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11238.21 Da
• Isoelectric Point: 9.5655

>AT154539 WP_017807009.1 NZ_CP051636:c1605332-1605030 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Nucleotide

• Length: 303 bp

>AT154539 NZ_CP068145:c2887430-2887128 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCTGCTGCACGGGTTCAGGCGGATGAGAT
CCTGCTGAATATCCATCTGGCGGAGCTGCGGGAGAAAGTGAAGAAAACACAGGTGGAAATGGCGCAGGCACTGGGAATAA
AACAGCCGACAGTCGCAGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGATGCCATC
GGCGGAAAACTGAATATTGATGTTGAACTGCCGGACGGCACGCATTATATGTTCCGGGTCTGA

Structures

Toxin

• AlphaFold DB: A0A380X0Q1