Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-Phd
Location 2258691..2259193 Replicon chromosome
Accession NZ_CP051635
Organism Treponema denticola strain OMZ 905

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E2EC53
Locus tag E4N86_RS10495 Protein ID WP_002672679.1
Coordinates 2258933..2259193 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E2ECR9
Locus tag E4N86_RS10490 Protein ID WP_002672677.1
Coordinates 2258691..2258933 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N86_RS10465 (E4N86_10490) 2254875..2256155 - 1281 WP_253717416.1 amino acid permease -
E4N86_RS10470 (E4N86_10495) 2256206..2256931 - 726 WP_253699219.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
E4N86_RS10475 (E4N86_10500) 2256985..2257947 - 963 WP_253717415.1 hypothetical protein -
E4N86_RS10480 (E4N86_10505) 2258131..2258364 + 234 WP_253717414.1 CopG family transcriptional regulator -
E4N86_RS10485 (E4N86_10510) 2258357..2258629 + 273 WP_002692432.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4N86_RS10490 (E4N86_10515) 2258691..2258933 + 243 WP_002672677.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E4N86_RS10495 (E4N86_10520) 2258933..2259193 + 261 WP_002672679.1 Txe/YoeB family addiction module toxin Toxin
E4N86_RS10500 (E4N86_10525) 2259242..2259652 + 411 WP_253717413.1 hypothetical protein -
E4N86_RS10505 (E4N86_10530) 2259879..2260598 + 720 WP_253717412.1 CPBP family intramembrane metalloprotease -
E4N86_RS10510 (E4N86_10535) 2260810..2261049 - 240 WP_253688729.1 DUF6364 family protein -
E4N86_RS10515 (E4N86_10540) 2261284..2262423 + 1140 WP_253717411.1 tRNA guanosine(34) transglycosylase Tgt -
E4N86_RS10520 (E4N86_10545) 2262491..2263960 + 1470 WP_253717410.1 HEAT repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(18-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10379.10 Da        Isoelectric Point: 10.1554

>T154531 WP_002672679.1 NZ_CP051635:2258933-2259193 [Treponema denticola]
MWNVVYSKQAAKDSKKIEQSNLKESVKRLIEVLKNDPFQNPPPYEKLIGDLTGKFSRRINLQHRLVYEVFEKEMIVRVLR
MWTHYE

Download         Length: 261 bp

>T154531 NZ_CP068143:773029-773205 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9175.34 Da        Isoelectric Point: 4.1317

>AT154531 WP_002672677.1 NZ_CP051635:2258691-2258933 [Treponema denticola]
MTIMTATAARTNLYNLIDRTKEFHEPIIISGKRNNAVLISEDDWNSIQETLYLCSIPGMRESILEASEESLEESVKELDW

Download         Length: 243 bp

>AT154531 NZ_CP068143:c773367-773193 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2EC53

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2ECR9

References