Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1487847..1488473 Replicon chromosome
Accession NZ_CP051635
Organism Treponema denticola strain OMZ 905

Toxin (Protein)


Gene name higB Uniprot ID Q73NN6
Locus tag E4N86_RS06815 Protein ID WP_002677634.1
Coordinates 1487847..1488155 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4N86_RS06820 Protein ID WP_253698449.1
Coordinates 1488165..1488473 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N86_RS06790 (E4N86_06810) 1483800..1484138 + 339 WP_010696721.1 anti-sigma factor antagonist -
E4N86_RS06795 (E4N86_06815) 1484155..1484697 + 543 WP_253698445.1 ATP-binding protein -
E4N86_RS06800 (E4N86_06820) 1484711..1485532 - 822 WP_253718222.1 hypothetical protein -
E4N86_RS06805 (E4N86_06825) 1485513..1486133 - 621 WP_253698447.1 hypothetical protein -
E4N86_RS06810 (E4N86_06830) 1486250..1487629 + 1380 WP_253698448.1 tyrosine phenol-lyase -
E4N86_RS06815 (E4N86_06835) 1487847..1488155 + 309 WP_002677634.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N86_RS06820 (E4N86_06840) 1488165..1488473 + 309 WP_253698449.1 NadS family protein Antitoxin
E4N86_RS06825 (E4N86_06845) 1488606..1489277 + 672 WP_253718221.1 TetR/AcrR family transcriptional regulator -
E4N86_RS06830 (E4N86_06850) 1489366..1489782 + 417 WP_252507806.1 SRPBCC family protein -
E4N86_RS06835 (E4N86_06855) 1489906..1490535 - 630 WP_253718220.1 adenylate kinase -
E4N86_RS06840 (E4N86_06860) 1490592..1491821 - 1230 WP_253698453.1 cation:dicarboxylase symporter family transporter -
E4N86_RS06845 (E4N86_06865) 1491860..1493179 - 1320 WP_253718218.1 leucine-rich repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11736.96 Da        Isoelectric Point: 10.6864

>T154527 WP_002677634.1 NZ_CP051635:1487847-1488155 [Treponema denticola]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Download         Length: 309 bp

>T154527 NZ_CP068143:599370-599474 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11579.46 Da        Isoelectric Point: 9.6884

>AT154527 WP_253698449.1 NZ_CP051635:1488165-1488473 [Treponema denticola]
MFKRKKMSDEMFTELLQSVKEAVLIEKGEIPPSRVFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Download         Length: 309 bp

>AT154527 NZ_CP068143:c599632-599469 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73NN6

Antitoxin

Source ID Structure

References