Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2408446..2409041 Replicon chromosome
Accession NZ_CP051630
Organism Pyruvatibacter mobilis strain CGMCC 1.15125

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HG718_RS11240 Protein ID WP_160586825.1
Coordinates 2408446..2408769 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HG718_RS11245 Protein ID WP_160586826.1
Coordinates 2408766..2409041 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG718_RS11215 2404210..2404518 - 309 WP_160586819.1 ferritin -
HG718_RS11220 2404559..2405650 - 1092 WP_160586820.1 glutathione S-transferase -
HG718_RS11225 2405693..2405758 - 66 WP_160586823.1 palindromic element RPE4 domain-containing protein -
HG718_RS11230 2405822..2406739 - 918 WP_160586821.1 alpha/beta hydrolase -
HG718_RS11235 2407453..2407935 + 483 WP_160586824.1 PH domain-containing protein -
HG718_RS11240 2408446..2408769 + 324 WP_160586825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HG718_RS11245 2408766..2409041 + 276 WP_160586826.1 helix-turn-helix domain-containing protein Antitoxin
HG718_RS11250 2409121..2409852 + 732 WP_160586827.1 TIGR02391 family protein -
HG718_RS11255 2410212..2412476 - 2265 WP_160586828.1 enoyl-CoA hydratase/isomerase family protein -
HG718_RS11260 2412653..2413858 - 1206 WP_160586829.1 acetyl-CoA C-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12118.24 Da        Isoelectric Point: 10.5419

>T154515 WP_160586825.1 NZ_CP051630:2408446-2408769 [Pyruvatibacter mobilis]
MSWRVEFLDDCVVAEIEALPADMQARFLRIAELIESVGLPAVGAPHIKHPDGKLWEMRMKGRDGIARAIYVTATGRRVIV
LHGFVKKTQKTPRRALEIARTRAEEVR

Download         Length: 324 bp

>T154515 NZ_CP068139:c1951444-1950911 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10044.71 Da        Isoelectric Point: 10.9252

>AT154515 WP_160586826.1 NZ_CP051630:2408766-2409041 [Pyruvatibacter mobilis]
MTKTLEAYRKKALRDPAVKAEYERLGPEFRIARAIIDARKTARLTQADLATRMGTTQSAIARMESGRQMPSTKTLMKVAE
ATGTELLVGFG

Download         Length: 276 bp

>AT154515 NZ_CP068139:c1951721-1951455 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References