Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-sokC/Ldr(toxin)
Location 4913786..4914007 Replicon chromosome
Accession NZ_CP051615
Organism Escherichia coli O25b:H4-ST131 strain 2017_APHA

Toxin (Protein)


Gene name ldrD Uniprot ID A0A1U9U3P9
Locus tag HHM36_RS23600 Protein ID WP_001531632.1
Coordinates 4913786..4913893 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4913941..4914007 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHM36_RS23575 4909630..4910712 + 1083 WP_000804726.1 peptide chain release factor 1 -
HHM36_RS23580 4910712..4911545 + 834 WP_000456450.1 peptide chain release factor N(5)-glutamine methyltransferase -
HHM36_RS23585 4911542..4911934 + 393 WP_000200375.1 invasion regulator SirB2 -
HHM36_RS23590 4911938..4912747 + 810 WP_001257044.1 invasion regulator SirB1 -
HHM36_RS23595 4912783..4913637 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
HHM36_RS23600 4913786..4913893 - 108 WP_001531632.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4913941..4914007 + 67 NuclAT_10 - Antitoxin
- 4913941..4914007 + 67 NuclAT_10 - Antitoxin
- 4913941..4914007 + 67 NuclAT_10 - Antitoxin
- 4913941..4914007 + 67 NuclAT_10 - Antitoxin
- 4913941..4914007 + 67 NuclAT_5 - Antitoxin
- 4913941..4914007 + 67 NuclAT_5 - Antitoxin
- 4913941..4914007 + 67 NuclAT_5 - Antitoxin
- 4913941..4914007 + 67 NuclAT_5 - Antitoxin
- 4913941..4914007 + 67 NuclAT_6 - Antitoxin
- 4913941..4914007 + 67 NuclAT_6 - Antitoxin
- 4913941..4914007 + 67 NuclAT_6 - Antitoxin
- 4913941..4914007 + 67 NuclAT_6 - Antitoxin
- 4913941..4914007 + 67 NuclAT_7 - Antitoxin
- 4913941..4914007 + 67 NuclAT_7 - Antitoxin
- 4913941..4914007 + 67 NuclAT_7 - Antitoxin
- 4913941..4914007 + 67 NuclAT_7 - Antitoxin
- 4913941..4914007 + 67 NuclAT_8 - Antitoxin
- 4913941..4914007 + 67 NuclAT_8 - Antitoxin
- 4913941..4914007 + 67 NuclAT_8 - Antitoxin
- 4913941..4914007 + 67 NuclAT_8 - Antitoxin
- 4913941..4914007 + 67 NuclAT_9 - Antitoxin
- 4913941..4914007 + 67 NuclAT_9 - Antitoxin
- 4913941..4914007 + 67 NuclAT_9 - Antitoxin
- 4913941..4914007 + 67 NuclAT_9 - Antitoxin
- 4913943..4914006 + 64 NuclAT_12 - -
- 4913943..4914006 + 64 NuclAT_12 - -
- 4913943..4914006 + 64 NuclAT_12 - -
- 4913943..4914006 + 64 NuclAT_12 - -
- 4913943..4914006 + 64 NuclAT_13 - -
- 4913943..4914006 + 64 NuclAT_13 - -
- 4913943..4914006 + 64 NuclAT_13 - -
- 4913943..4914006 + 64 NuclAT_13 - -
- 4913943..4914006 + 64 NuclAT_14 - -
- 4913943..4914006 + 64 NuclAT_14 - -
- 4913943..4914006 + 64 NuclAT_14 - -
- 4913943..4914006 + 64 NuclAT_14 - -
- 4913943..4914006 + 64 NuclAT_15 - -
- 4913943..4914006 + 64 NuclAT_15 - -
- 4913943..4914006 + 64 NuclAT_15 - -
- 4913943..4914006 + 64 NuclAT_15 - -
- 4913943..4914006 + 64 NuclAT_16 - -
- 4913943..4914006 + 64 NuclAT_16 - -
- 4913943..4914006 + 64 NuclAT_16 - -
- 4913943..4914006 + 64 NuclAT_16 - -
- 4913943..4914006 + 64 NuclAT_17 - -
- 4913943..4914006 + 64 NuclAT_17 - -
- 4913943..4914006 + 64 NuclAT_17 - -
- 4913943..4914006 + 64 NuclAT_17 - -
- 4913943..4914008 + 66 NuclAT_18 - -
- 4913943..4914008 + 66 NuclAT_18 - -
- 4913943..4914008 + 66 NuclAT_18 - -
- 4913943..4914008 + 66 NuclAT_18 - -
- 4913943..4914008 + 66 NuclAT_19 - -
- 4913943..4914008 + 66 NuclAT_19 - -
- 4913943..4914008 + 66 NuclAT_19 - -
- 4913943..4914008 + 66 NuclAT_19 - -
- 4913943..4914008 + 66 NuclAT_20 - -
- 4913943..4914008 + 66 NuclAT_20 - -
- 4913943..4914008 + 66 NuclAT_20 - -
- 4913943..4914008 + 66 NuclAT_20 - -
- 4913943..4914008 + 66 NuclAT_21 - -
- 4913943..4914008 + 66 NuclAT_21 - -
- 4913943..4914008 + 66 NuclAT_21 - -
- 4913943..4914008 + 66 NuclAT_21 - -
- 4913943..4914008 + 66 NuclAT_22 - -
- 4913943..4914008 + 66 NuclAT_22 - -
- 4913943..4914008 + 66 NuclAT_22 - -
- 4913943..4914008 + 66 NuclAT_22 - -
- 4913943..4914008 + 66 NuclAT_23 - -
- 4913943..4914008 + 66 NuclAT_23 - -
- 4913943..4914008 + 66 NuclAT_23 - -
- 4913943..4914008 + 66 NuclAT_23 - -
HHM36_RS23605 4914298..4915398 - 1101 WP_000063608.1 sodium-potassium/proton antiporter ChaA -
HHM36_RS23610 4915668..4915907 + 240 WP_000120702.1 putative cation transport regulator ChaB -
HHM36_RS23615 4916056..4916751 + 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
HHM36_RS23620 4916795..4917148 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -
HHM36_RS23625 4917333..4918727 + 1395 WP_000086187.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4040.89 Da        Isoelectric Point: 12.5163

>T154493 WP_001531632.1 NZ_CP051615:c4913893-4913786 [Escherichia coli O25b:H4-ST131]
MTLAQFAMIFWHNLAAPILAGIITAVIVSWWRNRK

Download         Length: 108 bp

>T154493 NZ_CP068103:c522207-521368 [Peptoniphilus harei]
ATGAATAAAGCAAAGTTAACCGCCATTTGTCATAATATAAGCAAAGAATCAGGACTCCCATTTAATTCAGTAATGTTATA
TTATTTTTTGGAAAGCATATTAAAAAAATTAGCACAGAGTAAGTATCATGAAAAATTTATTTTTAAAGGAGGTTTTCTTT
TATCTAATGTAGTAGGGATAGATTCAAGAAGCACAGTAGATATAGATCTTCTTTTAAGAAATATGCATTTATCAGAAGAA
AATGTATTAAAAACAATACAAGAATTACTAGAAGCAAGTCATTCAGATGATATATCCTATAAAGTAAATGGAATAAGTAC
AATCAAGGAAGATGACCAGTATGGAGGGTTTCGTGTAAGTATACTTTGTAGGATGGAGAATATAAGACAAATTGTACCTC
TTGATATTGCAACAGGTGATGTTATCACCCCACATCCCATAGATTATAAATATATAAGTGCTTTTGGGCAAGAAGATATT
TTAATTAAAGCCTATCCTATTGAAACAATTGTGGCAGAAAAAATTCAAACAATATACTCTAGGGGGTTTTTAAATAGCAG
AAGTAAGGATTACTATGATCTTTATATAATTTATAAATTAAAAGATAAAGAAATTGATACCAAGATATTAAAAGAAGCAT
GTATTAGAACTTTTGATTATAGAAAAACGGAATTTGATATAGATAAAATCATAAATTTAATGAGAATGCTAAAAACGGAT
CAAGCTTTTTTATACAGATGGAATTCTTATTCGAAGAAAAATCTTTATGCTAGAGACATAAAGTTTGAAGATGTAATAGA
TAATGGAATAAATATTATAGAAAAAATAAAAAATCAGTAG

Antitoxin


Download         Length: 67 bp

>AT154493 NZ_CP051615:4913941-4914007 [Escherichia coli O25b:H4-ST131]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9U3P9

Antitoxin

Download structure file

References