Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 790359..790861 | Replicon | chromosome |
Accession | NZ_CP051615 | ||
Organism | Escherichia coli O25b:H4-ST131 strain 2017_APHA |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | E2QNP2 |
Locus tag | HHM36_RS03985 | Protein ID | WP_000767819.1 |
Coordinates | 790359..790613 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | E2QNP3 |
Locus tag | HHM36_RS03990 | Protein ID | WP_001259253.1 |
Coordinates | 790610..790861 (-) | Length | 84 a.a. |
Genomic Context
Location: 791144..791194 (51 bp)
Type: Others
Protein ID: WP_001364200.1
Type: Others
Protein ID: WP_001364200.1
Location: 791340..792239 (900 bp)
Type: Others
Protein ID: WP_000131782.1
Type: Others
Protein ID: WP_000131782.1
Location: 792245..793549 (1305 bp)
Type: Others
Protein ID: WP_001296211.1
Type: Others
Protein ID: WP_001296211.1
Location: 793546..794616 (1071 bp)
Type: Others
Protein ID: WP_000108967.1
Type: Others
Protein ID: WP_000108967.1
Location: 794616..795683 (1068 bp)
Type: Others
Protein ID: WP_000080057.1
Type: Others
Protein ID: WP_000080057.1
Location: 786177..786635 (459 bp)
Type: Others
Protein ID: WP_001531805.1
Type: Others
Protein ID: WP_001531805.1
Location: 786852..788210 (1359 bp)
Type: Others
Protein ID: WP_000019194.1
Type: Others
Protein ID: WP_000019194.1
Location: 788200..788262 (63 bp)
Type: Others
Protein ID: WP_010723108.1
Type: Others
Protein ID: WP_010723108.1
Location: 788477..789406 (930 bp)
Type: Others
Protein ID: WP_000803366.1
Type: Others
Protein ID: WP_000803366.1
Location: 789452..790276 (825 bp)
Type: Others
Protein ID: WP_000754737.1
Type: Others
Protein ID: WP_000754737.1
Location: 790359..790613 (255 bp)
Type: Toxin
Protein ID: WP_000767819.1
Type: Toxin
Protein ID: WP_000767819.1
Location: 790610..790861 (252 bp)
Type: Antitoxin
Protein ID: WP_001259253.1
Type: Antitoxin
Protein ID: WP_001259253.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HHM36_RS03960 | 786177..786635 | - | 459 | WP_001531805.1 | IS200/IS605-like element IS200C family transposase | - |
HHM36_RS03965 | 786852..788210 | - | 1359 | WP_000019194.1 | putrescine/proton symporter PlaP | - |
HHM36_RS03970 | 788200..788262 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
HHM36_RS03975 | 788477..789406 | - | 930 | WP_000803366.1 | LysR family transcriptional regulator | - |
HHM36_RS03980 | 789452..790276 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
HHM36_RS03985 | 790359..790613 | - | 255 | WP_000767819.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
HHM36_RS03990 | 790610..790861 | - | 252 | WP_001259253.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
HHM36_RS03995 | 791144..791194 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
HHM36_RS04000 | 791340..792239 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
HHM36_RS04005 | 792245..793549 | + | 1305 | WP_001296211.1 | histidinol dehydrogenase | - |
HHM36_RS04010 | 793546..794616 | + | 1071 | WP_000108967.1 | histidinol-phosphate transaminase | - |
HHM36_RS04015 | 794616..795683 | + | 1068 | WP_000080057.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10110.53 Da Isoelectric Point: 7.2749
>T154475 WP_000767819.1 NZ_CP051615:c790613-790359 [Escherichia coli O25b:H4-ST131]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T154475 NZ_CP068090:c3381938-3381720 [Shigella boydii]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9365.62 Da Isoelectric Point: 4.6127
>AT154475 WP_001259253.1 NZ_CP051615:c790861-790610 [Escherichia coli O25b:H4-ST131]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE
Download Length: 252 bp
>AT154475 NZ_CP068090:c3382338-3381964 [Shigella boydii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG