Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 790359..790861 Replicon chromosome
Accession NZ_CP051615
Organism Escherichia coli O25b:H4-ST131 strain 2017_APHA

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag HHM36_RS03985 Protein ID WP_000767819.1
Coordinates 790359..790613 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag HHM36_RS03990 Protein ID WP_001259253.1
Coordinates 790610..790861 (-) Length 84 a.a.

Genomic Context


HHM36_RS03995HHM36_RS04000HHM36_RS04005HHM36_RS04010HHM36_RS04015HHM36_RS03960HHM36_RS03965HHM36_RS03970HHM36_RS03975HHM36_RS03980HHM36_RS03985HHM36_RS03990
Location: 791144..791194 (51 bp)
Type: Others
Protein ID: WP_001364200.1
Location: 791340..792239 (900 bp)
Type: Others
Protein ID: WP_000131782.1
Location: 792245..793549 (1305 bp)
Type: Others
Protein ID: WP_001296211.1
Location: 793546..794616 (1071 bp)
Type: Others
Protein ID: WP_000108967.1
Location: 794616..795683 (1068 bp)
Type: Others
Protein ID: WP_000080057.1
Location: 786177..786635 (459 bp)
Type: Others
Protein ID: WP_001531805.1
Location: 786852..788210 (1359 bp)
Type: Others
Protein ID: WP_000019194.1
Location: 788200..788262 (63 bp)
Type: Others
Protein ID: WP_010723108.1
Location: 788477..789406 (930 bp)
Type: Others
Protein ID: WP_000803366.1
Location: 789452..790276 (825 bp)
Type: Others
Protein ID: WP_000754737.1
Location: 790359..790613 (255 bp)
Type: Toxin
Protein ID: WP_000767819.1
Location: 790610..790861 (252 bp)
Type: Antitoxin
Protein ID: WP_001259253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HHM36_RS03960786177..786635-459WP_001531805.1IS200/IS605-like element IS200C family transposase-
HHM36_RS03965786852..788210-1359WP_000019194.1putrescine/proton symporter PlaP-
HHM36_RS03970788200..788262-63WP_010723108.1membrane protein YoeI-
HHM36_RS03975788477..789406-930WP_000803366.1LysR family transcriptional regulator-
HHM36_RS03980789452..790276-825WP_000754737.1SDR family oxidoreductase-
HHM36_RS03985790359..790613-255WP_000767819.1type II toxin-antitoxin system mRNA interferase toxin YoeBToxin
HHM36_RS03990790610..790861-252WP_001259253.1YoeB-YefM toxin-antitoxin system antitoxin YefMAntitoxin
HHM36_RS03995791144..791194+51WP_001364200.1his operon leader peptide-
HHM36_RS04000791340..792239+900WP_000131782.1ATP phosphoribosyltransferase-
HHM36_RS04005792245..793549+1305WP_001296211.1histidinol dehydrogenase-
HHM36_RS04010793546..794616+1071WP_000108967.1histidinol-phosphate transaminase-
HHM36_RS04015794616..795683+1068WP_000080057.1bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(1-72)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T154475 WP_000767819.1 NZ_CP051615:c790613-790359 [Escherichia coli O25b:H4-ST131]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T154475 NZ_CP068090:c3381938-3381720 [Shigella boydii]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT154475 WP_001259253.1 NZ_CP051615:c790861-790610 [Escherichia coli O25b:H4-ST131]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp

>AT154475 NZ_CP068090:c3382338-3381964 [Shigella boydii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBE2QNP2


Antitoxin

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Source
ID
Structure
AlphaFold DBE2QNP3

References