Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2888423..2889025 Replicon chromosome
Accession NZ_CP051609
Organism Escherichia coli O25b:H4-ST131 strain 2019_APHA

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag HHM37_RS13810 Protein ID WP_000897302.1
Coordinates 2888423..2888734 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HHM37_RS13815 Protein ID WP_000356397.1
Coordinates 2888735..2889025 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHM37_RS13785 2884337..2884936 + 600 WP_001296610.1 glucose-1-phosphatase -
HHM37_RS13790 2884930..2885802 + 873 WP_000920762.1 virulence factor BrkB family protein -
HHM37_RS13795 2885799..2886236 + 438 WP_000560981.1 D-tyrosyl-tRNA(Tyr) deacylase -
HHM37_RS13800 2886281..2887222 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
HHM37_RS13805 2887286..2888194 - 909 WP_001385591.1 alpha/beta hydrolase -
HHM37_RS13810 2888423..2888734 + 312 WP_000897302.1 hypothetical protein Toxin
HHM37_RS13815 2888735..2889025 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
HHM37_RS13820 2889384..2889662 + 279 WP_001296612.1 hypothetical protein -
HHM37_RS13825 2890059..2890277 + 219 WP_001251293.1 ribbon-helix-helix domain-containing protein -
HHM37_RS13830 2890462..2890911 - 450 WP_032140890.1 hypothetical protein -
HHM37_RS13835 2891227..2892075 - 849 WP_001038650.1 hypothetical protein -
HHM37_RS13840 2892365..2892607 + 243 WP_001068514.1 ribbon-helix-helix domain-containing protein -
HHM37_RS13845 2892789..2893718 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T154446 WP_000897302.1 NZ_CP051609:2888423-2888734 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T154446 NZ_CP068060:664218-665051 [Streptococcus anginosus]
ATGAATAAAGATAAGCTAAGAGCGATATGTCAAAAACTGTCAAAAGAAACAGGGCTTAGCTTTAATGCTGTGCAAACACA
CTATTTTTTAGAAAGCATTTTAGAGAAAATAGCAAGTAGTGACGAGAGTGAAAACTTTATTTTTAAAGGTGGTTTTTTAC
TCGCAAATGTAATTGGAATAAGGCAGAGAAACACAGTAGATATTGATTTTTTGATAAGAAGATTCTCACTTACTGAAGAA
AACATCAAGCAAAGATTTGAAAAAATTCTTCAAAGCGGAAACGATAATGGAATTACTTATGAGATTCAGAAAATAGAAGA
AATCCGTAAAGAAGATGAATATGGAGGATTTAGAATTACAGTTCTTTGTAGACTTGAAAATATCAGGCAGATTATTCCAC
TCGATATAGCAACAGGCGATCCAATTACACCAAGTGAAATATCCTATGAATATAAAAGTATTTTTAGTGATAAGTTTTTT
GAAATTTGTGCATATAATATAGAAACAATGCTTGCTGAGAAGATTCAGACAGTATATAAAAGAGGGGCGTTTAACAGCAG
AAGTAAGGATTTTTATGATATTTACATTCTATATCATTTGAAGAAAGAGGAAATAGACTTTGAGCATTTAAAGGAAGCTT
GTAAAAATACATTTAAGCATAGAAGCACAGATTTTAATATAGATAGTATTCTTGATGTATTAGTCGACTTAAAAATGGAA
AAAGACCTCAAAACAAGGTGGAGTAGCTATCAAAAAAGATTTAGTTATGCAGGAGAAATAAATTTTGATGCTGTAATAGA
TATTATGATAGAATTAGTGAAAAACATAAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT154446 WP_000356397.1 NZ_CP051609:2888735-2889025 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT154446 NZ_CP068060:663632-664225 [Streptococcus anginosus]
ATGGATTATATAAAAAAGATAAAAGAAAAATTGAATAAAACGGGTGGGGTTATTACAAGTAAGGAACTTAAAAATTCTAA
CATTCCTACAATATATCTCACACGAATGGTGGAAAAAGGTGAACTGATTCGTGCGGATAGAGGAATCTATATAGATTCAA
ACGGAGATTATGACGAGTATTATTTTTTTCATAATAGATGTAAGGTTGCTGTTTTTTCTTATGTATCCGCTCTTTATCTT
CAGGAGTTTACAGACATAATCCCGAATGAAATGGAAGTTACAGTATATAAAGGGTACAATCCACATCGTATAAGCGGAAA
TGTTAGAATTCACTATGTAACAAAAGAAATTTATGATTTGGGTATGACAGAATGCCAAACAATGTTTGGGAATACAGTAA
AAGTTTATGACTTGGAGAGAACAATTTGCGATTTTATTAAAAATAGAAGTGAAATAGAAACTGAACTGTTTTCCAAAACG
ATTAACAAGTATGTCCGTTATGAAAATAAGGATTTGAATAAACTATATGAGTATTCTAAAAAAATGAAGATATATGAAAA
AGTAAAAGAAATTTTGGAGGTTGTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References