Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2034017..2034744 | Replicon | chromosome |
| Accession | NZ_CP051609 | ||
| Organism | Escherichia coli O25b:H4-ST131 strain 2019_APHA | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U9ZMR4 |
| Locus tag | HHM37_RS09660 | Protein ID | WP_000550189.1 |
| Coordinates | 2034430..2034744 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HHM37_RS09655 | Protein ID | WP_000560269.1 |
| Coordinates | 2034017..2034433 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHM37_RS09645 | 2029377..2031728 | + | 2352 | WP_000695432.1 | alpha-glucosidase | - |
| HHM37_RS09650 | 2031954..2033972 | + | 2019 | WP_000121413.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
| HHM37_RS09655 | 2034017..2034433 | - | 417 | WP_000560269.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| HHM37_RS09660 | 2034430..2034744 | - | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| HHM37_RS09665 | 2035029..2036165 | - | 1137 | WP_000018703.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
| HHM37_RS09670 | 2036250..2036753 | + | 504 | WP_001295542.1 | M48 family metallopeptidase | - |
| HHM37_RS09675 | 2036830..2037522 | + | 693 | WP_000942551.1 | vancomycin high temperature exclusion protein | - |
| HHM37_RS09680 | 2037601..2038587 | + | 987 | WP_001385498.1 | Gfo/Idh/MocA family oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T154443 WP_000550189.1 NZ_CP051609:c2034744-2034430 [Escherichia coli O25b:H4-ST131]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T154443 NZ_CP068057:c667412-666636 [Streptococcus dysgalactiae]
ATGGCTCTGGCAGACTATCATCAAGATGACTTTGACTTTGCCTTAAAACGAACCATTCGTTCTTTAACTCGTGGCAAAGA
GACATCAGTTAATCCAAATGCAATTTTACTTGGCGGACAAAGCGGAGCAGGTAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTTCAAGGGAATATCGTCATTATAGACGGTGATAGTTATCGCTCTTTACACCCGAACTATCTAGCTTTACAAGAA
GAATACAGTAAAGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACATCTTGTCGATGAACTCAGCAA
GCAAGGTTATCATTTATTAATTGAAGGAACCTTGAGAACGGCAGAAGTCCGACGAAAAACAGCTCAGTTATTGAAATCAA
GAGGCTATCAAGTCTCGTTAGCTTTGATAGCAACCAAACCTGAATTGTCCTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGCGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGCTATTGTAGAGCATTTAGTTGATAA
CTTACGAGAGTTAGAAACTGATAAACTCTTTGACCAGATTCAAATTTATCAAAGAGACAGACGTTGTGTCTATGATTCTG
AAACAGATAAAGGTTCAGCAGCCGATGTCCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTAGAGGAGGAGATGATG
AAGGTGGGACAGGAACAGTTGAGGGAAGTAGGTAGAAGGAATGAAAAAGATGCATAG
ATGGCTCTGGCAGACTATCATCAAGATGACTTTGACTTTGCCTTAAAACGAACCATTCGTTCTTTAACTCGTGGCAAAGA
GACATCAGTTAATCCAAATGCAATTTTACTTGGCGGACAAAGCGGAGCAGGTAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTTCAAGGGAATATCGTCATTATAGACGGTGATAGTTATCGCTCTTTACACCCGAACTATCTAGCTTTACAAGAA
GAATACAGTAAAGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACATCTTGTCGATGAACTCAGCAA
GCAAGGTTATCATTTATTAATTGAAGGAACCTTGAGAACGGCAGAAGTCCGACGAAAAACAGCTCAGTTATTGAAATCAA
GAGGCTATCAAGTCTCGTTAGCTTTGATAGCAACCAAACCTGAATTGTCCTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGCGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGCTATTGTAGAGCATTTAGTTGATAA
CTTACGAGAGTTAGAAACTGATAAACTCTTTGACCAGATTCAAATTTATCAAAGAGACAGACGTTGTGTCTATGATTCTG
AAACAGATAAAGGTTCAGCAGCCGATGTCCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTAGAGGAGGAGATGATG
AAGGTGGGACAGGAACAGTTGAGGGAAGTAGGTAGAAGGAATGAAAAAGATGCATAG
Antitoxin
Download Length: 139 a.a. Molecular weight: 15023.47 Da Isoelectric Point: 4.4547
>AT154443 WP_000560269.1 NZ_CP051609:c2034433-2034017 [Escherichia coli O25b:H4-ST131]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFVEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFVEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT154443 NZ_CP068057:c667888-667412 [Streptococcus dysgalactiae]
ATGATTGGAGAGAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
ACGAAATAGCCTTAGCCGTTATGAAAATGGTACGAGTTCAGTCACAACAGAACTTATAGACTGCATTTGTCAGAAATTCA
ATGTTTCTTATGTTGATATTGTAGGAGAAGAGAAGATGTTAACACCAGTAGAAGATTATCAATTGACGCTAAAAATAGAA
GTCATCAAAGAGCGTGGCGCAGCGATTTTATCTCAACTATATCGCTATCAAGATAGTCAAGGAATCGCTTTTGACGATGA
GACCAATCCTTGGATTTTAATGAGTGATGACTTGTCAGACCTTATCAATACCAAGATTTACCTTGTTAATACGTTTGATG
AAGTGGAGCGTTACAATGGTTATTTGGATGGTATTGAGCGCATGTTGGTACTTGCTCGTCATCAGGTGGTGGCTTAA
ATGATTGGAGAGAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
ACGAAATAGCCTTAGCCGTTATGAAAATGGTACGAGTTCAGTCACAACAGAACTTATAGACTGCATTTGTCAGAAATTCA
ATGTTTCTTATGTTGATATTGTAGGAGAAGAGAAGATGTTAACACCAGTAGAAGATTATCAATTGACGCTAAAAATAGAA
GTCATCAAAGAGCGTGGCGCAGCGATTTTATCTCAACTATATCGCTATCAAGATAGTCAAGGAATCGCTTTTGACGATGA
GACCAATCCTTGGATTTTAATGAGTGATGACTTGTCAGACCTTATCAATACCAAGATTTACCTTGTTAATACGTTTGATG
AAGTGGAGCGTTACAATGGTTATTTGGATGGTATTGAGCGCATGTTGGTACTTGCTCGTCATCAGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|