Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5261759..5262354 Replicon chromosome
Accession NZ_CP051547
Organism Pseudomonas aeruginosa strain AA2

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag HHA37_RS24350 Protein ID WP_003113526.1
Coordinates 5262076..5262354 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HHA37_RS24345 Protein ID WP_003099268.1
Coordinates 5261759..5262064 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHA37_RS24310 5256899..5257747 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
HHA37_RS24320 5257914..5258855 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
HHA37_RS24325 5258972..5259586 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
HHA37_RS24330 5259628..5260212 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
HHA37_RS24335 5260253..5261353 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
HHA37_RS24345 5261759..5262064 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
HHA37_RS24350 5262076..5262354 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHA37_RS24355 5262683..5264911 + 2229 WP_021264080.1 TonB-dependent receptor -
HHA37_RS24360 5264981..5265628 - 648 WP_003095021.1 carbonate dehydratase -
HHA37_RS24365 5265690..5266928 - 1239 WP_019681675.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T154413 WP_003113526.1 NZ_CP051547:c5262354-5262076 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T154413 NZ_CP068041:c2682591-2682488 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT154413 WP_003099268.1 NZ_CP051547:c5262064-5261759 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT154413 NZ_CP068041:2682450-2682721 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References