Detailed information of TA system TA154402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 659534..660122
• Replicon: chromosome
• Accession: NZ_CP051539
• Organism: Helicobacter pylori strain LIM-003

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: M3P300
• Locus tag: HG576_RS03185
• Protein ID: WP_000921941.1
• Coordinates: 659841..660122 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HG576_RS03180
• Protein ID: WP_202139139.1
• Coordinates: 659534..659848 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG576_RS03170	655936..657996	+	2061	WP_202139137.1	cadmium-translocating P-type ATPase	-
HG576_RS03175	658040..659338	+	1299	WP_202139138.1	restriction endonuclease subunit S	-
HG576_RS03180	659534..659848	+	315	WP_202139139.1	hypothetical protein	Antitoxin
HG576_RS03185	659841..660122	+	282	WP_000921941.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HG576_RS03190	660391..660648	-	258	Protein_623	type IV secretory system conjugative DNA transfer family protein	-
HG576_RS03195	660712..660879	+	168	Protein_624	restriction endonuclease subunit S	-
HG576_RS03200	661224..662723	-	1500	WP_202139140.1	outer membrane family protein	-
HG576_RS03205	663003..664235	-	1233	WP_001133745.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10891.80 Da
• Isoelectric Point: 9.5726

>T154402 WP_000921941.1 NZ_CP051539:659841-660122 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T154402 NZ_CP068040:c124150-123869 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCAAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAATGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTG
TATATTCTGCGAGTGTTGCATACAGCACAGAAGTGGCCATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12203.68 Da
• Isoelectric Point: 6.2290

>AT154402 WP_202139139.1 NZ_CP051539:659534-659848 [Helicobacter pylori]
MPNVITDYSQYNEKQLHNFLNSIKKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTINSKDDPE
CDVSFGDFNDFLQIARQERERHNA

Nucleotide

• Length: 315 bp

>AT154402 NZ_CP068040:c124416-124147 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCGGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCTCATGACATGGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: M3P300