154400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 995810..996398 Replicon chromosome
Accession NZ_CP051537
Organism Helicobacter pylori strain LIM-005

Toxin (Protein)


Gene name TfiT Uniprot ID Q6RWC1
Locus tag HG578_RS04645 Protein ID WP_000921939.1
Coordinates 995810..996091 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID I9TJZ8
Locus tag HG578_RS04650 Protein ID WP_000073112.1
Coordinates 996084..996398 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG578_RS04620 991664..992522 + 859 Protein_899 Flp pilus assembly complex ATPase component TadA -
HG578_RS04625 992519..992974 + 456 WP_202134512.1 mobilization protein -
HG578_RS04630 992971..993261 + 291 WP_000159808.1 hypothetical protein -
HG578_RS04635 993262..993819 + 558 WP_202134513.1 hypothetical protein -
HG578_RS04640 993820..995568 + 1749 WP_202134514.1 type IV secretory system conjugative DNA transfer family protein -
HG578_RS04645 995810..996091 - 282 WP_000921939.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HG578_RS04650 996084..996398 - 315 WP_000073112.1 hypothetical protein Antitoxin
HG578_RS04655 996698..998611 + 1914 WP_202134515.1 relaxase/mobilization nuclease domain-containing protein -
HG578_RS04660 998636..999809 - 1174 Protein_907 hypothetical protein -
HG578_RS04665 999853..1000137 - 285 WP_000394655.1 hypothetical protein -
HG578_RS04670 1000220..1000876 - 657 WP_000587379.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 947021..1030896 83875


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10905.83 Da        Isoelectric Point: 9.5726

>T154400 WP_000921939.1 NZ_CP051537:c996091-995810 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T154400 NZ_CP068040:c102476-102318 [Escherichia coli]
ATGAAACTGCCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTATGCGAAATTCGTTACAGAGACGGGGACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12092.53 Da        Isoelectric Point: 5.2066

>AT154400 WP_000073112.1 NZ_CP051537:c996398-996084 [Helicobacter pylori]
MSNVITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT154400 NZ_CP068040:c102676-102528 [Escherichia coli]
CAGGGTGCAGACATATGGGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGT
GTTGTGTGGCAGAAAGAAGATAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGCATCCCATATGTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4ZKZ6

Antitoxin

Source ID Structure
AlphaFold DB I9TJZ8

References