154395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 995814..996402 Replicon chromosome
Accession NZ_CP051536
Organism Helicobacter pylori strain LIM-007

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag HG580_RS04720 Protein ID WP_202145484.1
Coordinates 995814..996095 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag HG580_RS04725 Protein ID WP_202145485.1
Coordinates 996088..996402 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG580_RS04690 991010..991273 + 264 WP_000564645.1 hypothetical protein -
HG580_RS04695 991573..992514 + 942 WP_000625128.1 Flp pilus assembly complex ATPase component TadA -
HG580_RS04700 992511..992966 + 456 WP_202145480.1 mobilization protein -
HG580_RS04705 992963..993253 + 291 WP_202145481.1 hypothetical protein -
HG580_RS04710 993254..993811 + 558 WP_202145482.1 hypothetical protein -
HG580_RS04715 993812..995539 + 1728 WP_202145483.1 type IV secretory system conjugative DNA transfer family protein -
HG580_RS04720 995814..996095 - 282 WP_202145484.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HG580_RS04725 996088..996402 - 315 WP_202145485.1 hypothetical protein Antitoxin
HG580_RS04730 996686..998593 + 1908 WP_202145486.1 relaxase/mobilization nuclease domain-containing protein -
HG580_RS04735 998618..999799 - 1182 WP_202145487.1 hypothetical protein -
HG580_RS04740 999831..1000115 - 285 WP_000394644.1 hypothetical protein -
HG580_RS04745 1000200..1000648 - 449 Protein_925 ParA family protein -
HG580_RS04750 1000696..1000914 + 219 WP_001105128.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10968.93 Da        Isoelectric Point: 10.0522

>T154395 WP_202145484.1 NZ_CP051536:c996095-995814 [Helicobacter pylori]
MPKVRTKKDFLKDFNKHILSGRITESDVARVVDCLKEQKPLQQKYCNHVLSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHNELFKK

Download         Length: 282 bp

>T154395 NZ_CP068036:c44654-44472 [Escherichia coli]
ATGAAATCTGCTGACCTGTTGAAAGAACTGATAGCTGCTGGTTGTGAGTTGAAGCGGCATAAGGCGAGCAGCCACCAGAT
ATGGTGGTCGCCCATAACAGGAAAAACTTTTCCTGTGCCCCATCCGAAAAAAGACTTGCCACTGGGTACTGTCAGATCGA
TCAGAAAAATGGCGGGGATTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12087.57 Da        Isoelectric Point: 4.9308

>AT154395 WP_202145485.1 NZ_CP051536:c996402-996088 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERCNA

Download         Length: 315 bp

>AT154395 NZ_CP068036:c44447-44010 [Escherichia coli]
ATGTTTTTTTCTGTGGGTGTCGAAACACCGAAGGATGACCATACGGCATATGGTATAACCGTTCCGGCTTTTGATCGTTT
TGATTTTGGCTGTGTCTCTGCTGCCGATACTCAATCAGAAATTCCTGTGATGGCGCGAGAAGCGATATTGGCTATCGTAG
AAGAAATGGTTTTAAGTGGTTCTTATTCTGTTGATGATATTCATGATGACGGCTGTTTAACATATGCCGCAAATCAGGAC
TATAGTCACTGCGATAGCTGGTTTGTAATTGATGTTGATTTGTCTGAAATTGAAGGTAAACAACAACGTATTAATATTGC
GTTGCCTGATGTGTTGATTCGTCGTATTGATGGATTTGTCAAAGAAAGTGGCGGTGTTTACAGAGATCGTAGCCATTTTC
TTGCTCAGGCCGCGCGGCATGAGCTTTCATATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References