Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1479144..1479732 Replicon chromosome
Accession NZ_CP051535
Organism Helicobacter pylori strain LIM-008

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag HG581_RS07010 Protein ID WP_140536263.1
Coordinates 1479451..1479732 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag HG581_RS07005 Protein ID WP_202137924.1
Coordinates 1479144..1479458 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG581_RS06985 1474667..1475323 + 657 WP_000587413.1 ParA family protein -
HG581_RS06990 1475404..1475688 + 285 WP_000394655.1 hypothetical protein -
HG581_RS06995 1475732..1476910 + 1179 WP_202137922.1 hypothetical protein -
HG581_RS07000 1476935..1478845 - 1911 WP_202137923.1 relaxase/mobilization nuclease domain-containing protein -
HG581_RS07005 1479144..1479458 + 315 WP_202137924.1 hypothetical protein Antitoxin
HG581_RS07010 1479451..1479732 + 282 WP_140536263.1 YafQ family addiction module toxin Toxin
HG581_RS07015 1480185..1480613 - 429 WP_001878871.1 IS200/IS605 family transposase -
HG581_RS07020 1480682..1481965 + 1284 WP_202137733.1 transposase -
HG581_RS07025 1481922..1483625 - 1704 WP_202137925.1 type IV secretory system conjugative DNA transfer family protein -
HG581_RS07030 1483626..1484183 - 558 WP_202137926.1 hypothetical protein -
HG581_RS07035 1484184..1484474 - 291 WP_202137927.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1451276..1488432 37156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10886.76 Da        Isoelectric Point: 9.5726

>T154393 WP_140536263.1 NZ_CP051535:1479451-1479732 [Helicobacter pylori]
ILKVRTKKDFLKDFNKHILSGRITENDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T154393 NZ_CP068035:c4836152-4835625 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12256.64 Da        Isoelectric Point: 4.9440

>AT154393 WP_202137924.1 NZ_CP051535:1479144-1479458 [Helicobacter pylori]
MSNVITDYSQYNEKQLQHFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIARQERERHDT

Download         Length: 315 bp

>AT154393 NZ_CP068035:c4836425-4836159 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References