Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1241302..1241928 Replicon chromosome
Accession NZ_CP051522
Organism Treponema denticola strain OMZ 910

Toxin (Protein)


Gene name higB Uniprot ID Q73NN6
Locus tag E4N87_RS05740 Protein ID WP_002677634.1
Coordinates 1241620..1241928 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4N87_RS05735 Protein ID WP_253698449.1
Coordinates 1241302..1241610 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N87_RS05710 (E4N87_05710) 1236596..1237915 + 1320 WP_253718218.1 leucine-rich repeat domain-containing protein -
E4N87_RS05715 (E4N87_05715) 1237954..1239183 + 1230 WP_253698453.1 cation:dicarboxylase symporter family transporter -
E4N87_RS05720 (E4N87_05720) 1239240..1239869 + 630 WP_253718220.1 adenylate kinase -
E4N87_RS05725 (E4N87_05725) 1239993..1240409 - 417 WP_252507806.1 SRPBCC family protein -
E4N87_RS05730 (E4N87_05730) 1240498..1241169 - 672 WP_253718221.1 TetR/AcrR family transcriptional regulator -
E4N87_RS05735 (E4N87_05735) 1241302..1241610 - 309 WP_253698449.1 NadS family protein Antitoxin
E4N87_RS05740 (E4N87_05740) 1241620..1241928 - 309 WP_002677634.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N87_RS05745 (E4N87_05745) 1242146..1243525 - 1380 WP_253698448.1 tyrosine phenol-lyase -
E4N87_RS05750 (E4N87_05750) 1243642..1244262 + 621 WP_253698447.1 hypothetical protein -
E4N87_RS05755 (E4N87_05755) 1244243..1245064 + 822 WP_253718222.1 hypothetical protein -
E4N87_RS05760 (E4N87_05760) 1245078..1245620 - 543 WP_253698445.1 ATP-binding protein -
E4N87_RS05765 (E4N87_05765) 1245637..1245975 - 339 WP_010696721.1 anti-sigma factor antagonist -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11736.96 Da        Isoelectric Point: 10.6864

>T154378 WP_002677634.1 NZ_CP051522:c1241928-1241620 [Treponema denticola]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Download         Length: 309 bp

>T154378 NZ_CP068035:c2217971-2217864 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11579.46 Da        Isoelectric Point: 9.6884

>AT154378 WP_253698449.1 NZ_CP051522:c1241610-1241302 [Treponema denticola]
MFKRKKMSDEMFTELLQSVKEAVLIEKGEIPPSRVFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Download         Length: 309 bp

>AT154378 NZ_CP068035:2218018-2218084 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73NN6

Antitoxin

Source ID Structure

References