Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-Phd |
| Location | 470541..471043 | Replicon | chromosome |
| Accession | NZ_CP051522 | ||
| Organism | Treponema denticola strain OMZ 910 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A0E2EC53 |
| Locus tag | E4N87_RS02070 | Protein ID | WP_002672679.1 |
| Coordinates | 470541..470801 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A0E2ECR9 |
| Locus tag | E4N87_RS02075 | Protein ID | WP_002672677.1 |
| Coordinates | 470801..471043 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4N87_RS02045 (E4N87_02035) | 465774..467243 | - | 1470 | WP_253717410.1 | HEAT repeat domain-containing protein | - |
| E4N87_RS02050 (E4N87_02040) | 467311..468450 | - | 1140 | WP_253717411.1 | tRNA guanosine(34) transglycosylase Tgt | - |
| E4N87_RS02055 (E4N87_02045) | 468685..468924 | + | 240 | WP_253688729.1 | DUF6364 family protein | - |
| E4N87_RS02060 (E4N87_02050) | 469136..469855 | - | 720 | WP_253717412.1 | CPBP family intramembrane metalloprotease | - |
| E4N87_RS02065 (E4N87_02055) | 470082..470492 | - | 411 | WP_253717413.1 | hypothetical protein | - |
| E4N87_RS02070 (E4N87_02060) | 470541..470801 | - | 261 | WP_002672679.1 | Txe/YoeB family addiction module toxin | Toxin |
| E4N87_RS02075 (E4N87_02065) | 470801..471043 | - | 243 | WP_002672677.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| E4N87_RS02080 (E4N87_02070) | 471105..471377 | - | 273 | WP_002692432.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| E4N87_RS02085 (E4N87_02075) | 471370..471603 | - | 234 | WP_253717414.1 | CopG family transcriptional regulator | - |
| E4N87_RS02090 (E4N87_02080) | 471787..472749 | + | 963 | WP_253717415.1 | hypothetical protein | - |
| E4N87_RS02095 (E4N87_02085) | 472803..473528 | + | 726 | WP_253699219.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| E4N87_RS02100 (E4N87_02090) | 473579..474859 | + | 1281 | WP_253717416.1 | amino acid permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10379.10 Da Isoelectric Point: 10.1554
>T154374 WP_002672679.1 NZ_CP051522:c470801-470541 [Treponema denticola]
MWNVVYSKQAAKDSKKIEQSNLKESVKRLIEVLKNDPFQNPPPYEKLIGDLTGKFSRRINLQHRLVYEVFEKEMIVRVLR
MWTHYE
MWNVVYSKQAAKDSKKIEQSNLKESVKRLIEVLKNDPFQNPPPYEKLIGDLTGKFSRRINLQHRLVYEVFEKEMIVRVLR
MWTHYE
Download Length: 261 bp
>T154374 NZ_CP068035:c746143-745886 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9175.34 Da Isoelectric Point: 4.1317
>AT154374 WP_002672677.1 NZ_CP051522:c471043-470801 [Treponema denticola]
MTIMTATAARTNLYNLIDRTKEFHEPIIISGKRNNAVLISEDDWNSIQETLYLCSIPGMRESILEASEESLEESVKELDW
MTIMTATAARTNLYNLIDRTKEFHEPIIISGKRNNAVLISEDDWNSIQETLYLCSIPGMRESILEASEESLEESVKELDW
Download Length: 243 bp
>AT154374 NZ_CP068035:c745874-745329 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2EC53 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2ECR9 |