Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-Phd
Location 470541..471043 Replicon chromosome
Accession NZ_CP051522
Organism Treponema denticola strain OMZ 910

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E2EC53
Locus tag E4N87_RS02070 Protein ID WP_002672679.1
Coordinates 470541..470801 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E2ECR9
Locus tag E4N87_RS02075 Protein ID WP_002672677.1
Coordinates 470801..471043 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N87_RS02045 (E4N87_02035) 465774..467243 - 1470 WP_253717410.1 HEAT repeat domain-containing protein -
E4N87_RS02050 (E4N87_02040) 467311..468450 - 1140 WP_253717411.1 tRNA guanosine(34) transglycosylase Tgt -
E4N87_RS02055 (E4N87_02045) 468685..468924 + 240 WP_253688729.1 DUF6364 family protein -
E4N87_RS02060 (E4N87_02050) 469136..469855 - 720 WP_253717412.1 CPBP family intramembrane metalloprotease -
E4N87_RS02065 (E4N87_02055) 470082..470492 - 411 WP_253717413.1 hypothetical protein -
E4N87_RS02070 (E4N87_02060) 470541..470801 - 261 WP_002672679.1 Txe/YoeB family addiction module toxin Toxin
E4N87_RS02075 (E4N87_02065) 470801..471043 - 243 WP_002672677.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E4N87_RS02080 (E4N87_02070) 471105..471377 - 273 WP_002692432.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4N87_RS02085 (E4N87_02075) 471370..471603 - 234 WP_253717414.1 CopG family transcriptional regulator -
E4N87_RS02090 (E4N87_02080) 471787..472749 + 963 WP_253717415.1 hypothetical protein -
E4N87_RS02095 (E4N87_02085) 472803..473528 + 726 WP_253699219.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
E4N87_RS02100 (E4N87_02090) 473579..474859 + 1281 WP_253717416.1 amino acid permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(18-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10379.10 Da        Isoelectric Point: 10.1554

>T154374 WP_002672679.1 NZ_CP051522:c470801-470541 [Treponema denticola]
MWNVVYSKQAAKDSKKIEQSNLKESVKRLIEVLKNDPFQNPPPYEKLIGDLTGKFSRRINLQHRLVYEVFEKEMIVRVLR
MWTHYE

Download         Length: 261 bp

>T154374 NZ_CP068035:c746143-745886 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9175.34 Da        Isoelectric Point: 4.1317

>AT154374 WP_002672677.1 NZ_CP051522:c471043-470801 [Treponema denticola]
MTIMTATAARTNLYNLIDRTKEFHEPIIISGKRNNAVLISEDDWNSIQETLYLCSIPGMRESILEASEESLEESVKELDW

Download         Length: 243 bp

>AT154374 NZ_CP068035:c745874-745329 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2EC53

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2ECR9

References