Detailed information of TA system TA154367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2226538..2227084
• Replicon: chromosome
• Accession: NZ_CP051515
• Organism: Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HF916_RS21775
• Protein ID: WP_168790883.1
• Coordinates: 2226538..2226780 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HF916_RS21780
• Protein ID: WP_168790884.1
• Coordinates: 2226791..2227084 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF916_RS21755	2221885..2223489	+	1605	WP_168790879.1	iron ABC transporter permease	-
HF916_RS21760	2223518..2224576	+	1059	WP_168790880.1	ABC transporter ATP-binding protein	-
HF916_RS21765	2224561..2225439	-	879	WP_168790881.1	LysR family transcriptional regulator	-
HF916_RS21770	2225541..2226461	+	921	WP_168790882.1	DMT family transporter	-
HF916_RS21775	2226538..2226780	-	243	WP_168790883.1	Txe/YoeB family addiction module toxin	Toxin
HF916_RS21780	2226791..2227084	-	294	WP_168790884.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HF916_RS21785	2227348..2228646	-	1299	WP_206001836.1	MFS transporter	-
HF916_RS21790	2228824..2229597	+	774	WP_168790886.1	GntR family transcriptional regulator	-
HF916_RS21795	2229606..2231288	+	1683	WP_168790887.1	malonate decarboxylase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9537.95 Da
• Isoelectric Point: 8.4749

>T154367 WP_168790883.1 NZ_CP051515:c2226780-2226538 [Paraburkholderia aromaticivorans]
MFTDDAWDDYLYWQETDRKVLRKINTLLEECRRDPYRGTGKPEALLGSLSGLWSRRITLADRLVYLPRDGKIYVIACRFH

Nucleotide

• Length: 243 bp

>T154367 NZ_CP068033:c4592187-4591810 [Klebsiella pneumoniae]
ATGCAAACCCAACCGCTATCCTCCACGCAGGAGGCTTCGCCACGCCCGTCACAGGTGGATATCTGGCAGCAGCTTCTGAG
TCACCTGCTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCATTTGGTCACGATGGCGTGATTCAGGAGCATATCG
ACGCGGGTATCTCACTGTGCGATGCCGTGAATGTTATCGTGGAAAAGTACGATCTGGTGCGCACCGATCGTCCCGGTTTC
AGCGCAGAAACACAGTCGCCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGCAA
CGACTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGAGGTGCAGCCATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10762.16 Da
• Isoelectric Point: 8.0098

>AT154367 WP_168790884.1 NZ_CP051515:c2227084-2226791 [Paraburkholderia aromaticivorans]
MNVLTYSEARAGFKQAMDDVCRDHTPMLITRQTGENVVMVSLEDFNAMQETLYLLSSSKNAQRLARSIAQLNAGSATARE
LLTDEQTQKPQRGGRKG

Nucleotide

• Length: 294 bp

>AT154367 NZ_CP068033:c4592652-4592239 [Klebsiella pneumoniae]
ATGTCGTCCTGCGCAGTGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATCGCTGAACCCTGGTGGGGCCTTAAGCCCACCGTCACACCGTGCTTTGGCGCACGACTGGTGCAGGAGGGCA
ACCAGGTGCACTATCTCGCCGACCGCGCCAGCATCACCGGTCAGTTCAGCGAGGCGGATTTACGCCATCTTGACCAGGCC
TTTCCGGTACTACTCAAACAGCTGGAATTGATGCTGGTTTCCGGTGAACTCAATCCTCACCATCAACACGGCGTTACGCT
CTACGCAAAAGGGTTGACCTGCGAAGCCGATTCACTCGGCTCGCATGGCTACATTTATATTGCGATTTATCCAACGCCTG
CAGCAACCGCGTAA