Detailed information of TA system TA154359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 1391483..1392071
• Replicon: chromosome
• Accession: NZ_CP051511
• Organism: Helicobacter pylori strain ASHA-006

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: M3P300
• Locus tag: HGK51_RS06720
• Protein ID: WP_000921941.1
• Coordinates: 1391790..1392071 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HGK51_RS06715
• Protein ID: WP_000065282.1
• Coordinates: 1391483..1391797 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGK51_RS06695	1387068..1387724	+	657	WP_202170693.1	ParA family protein	-
HGK51_RS06700	1387809..1388078	+	270	WP_000394632.1	hypothetical protein	-
HGK51_RS06705	1388110..1389288	+	1179	WP_202170694.1	hypothetical protein	-
HGK51_RS06710	1389313..1391220	-	1908	WP_202170695.1	relaxase/mobilization nuclease domain-containing protein	-
HGK51_RS06715	1391483..1391797	+	315	WP_000065282.1	hypothetical protein	Antitoxin
HGK51_RS06720	1391790..1392071	+	282	WP_000921941.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HGK51_RS06725	1392346..1394073	-	1728	WP_001208196.1	type IV secretory system conjugative DNA transfer family protein	-
HGK51_RS06730	1394074..1394631	-	558	WP_202170696.1	hypothetical protein	-
HGK51_RS06735	1394632..1394922	-	291	WP_000159821.1	hypothetical protein	-
HGK51_RS06740	1394919..1395374	-	456	WP_202170697.1	mobilization protein	-
HGK51_RS06745	1395371..1396312	-	942	WP_000625128.1	Flp pilus assembly complex ATPase component TadA	-
HGK51_RS06750	1396312..1396611	-	300	WP_000660135.1	hypothetical protein	-
HGK51_RS06755	1396608..1396871	-	264	WP_000564645.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10891.80 Da
• Isoelectric Point: 9.5726

>T154359 WP_000921941.1 NZ_CP051511:1391790-1392071 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T154359 NZ_CP068031:961710-961883 [Staphylococcus saccharolyticus]
ATGTCGAATAAAAAGAATTCTAAATTAAATTATCATGAAGAAGAAAATGCAATGGTATCAGATTTAGATGATTTAAAAGA
ATTAGGTAAAGAGATGGAACATATTTCTGAGAAGAATGATGAAAATAAAGTTAATCAATCTCATGATGAGATTTGTTCTG
ATAAAACTAACTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12126.64 Da
• Isoelectric Point: 5.2248

>AT154359 WP_000065282.1 NZ_CP051511:1391483-1391797 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKKKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDNPE
CDVSFGDFNDFLQIAKQERERQDA

Nucleotide

• Length: 315 bp

>AT154359 NZ_CP068031:961086-961685 [Staphylococcus saccharolyticus]
ATGGCAATGAACTTTAAAGTATTTGATAATAATGATAGAGTAGCAGAATACGCTGCTGATATTATTCGCAAACAATTTAA
TAATAATCCTACAACAATTGCAGGGTTTCACTTAGATCAAGAACATGCACCTGTTCTTGATGAACTTAAGAAAAATGTCG
ACTGCCATGCTGTTGATTTCAGTCAAATTAACATTTTAGATTATGATAATAATCGTTCTTACTATGAAATATTAGGAGTT
CCAGAAGGTCAAGTGTATTCAATTTCTTATGATCAAGATGCAATTGAATTTATTTCAGACAAGATGAAAACGAAAGAAAA
TAAAGGTAAACTTATTTTACAAGTATTATCAATTGATGAAAATGGAAAATTAGACGTTAATGTACGCCAAGGGTTGATGG
AAGCTAGAGAAATTTTCCTTATCATTACAGGCAGTCAAAAACGTGATGTTGTTGAAAAATTATATCGCGAGAATGGCAAA
TCTAGTTATGAACCAGCTGATTTAAAAGCACACCGTATGGTCAATGTTATTTTAGATAAAGAATCAGCAGAAGGTTTACC
TGAAGATGTTAAAGAGTACTTCACAGCGCGTTTTGCATAA

Structures

Toxin

• AlphaFold DB: M3P300