Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 344312..344900 Replicon chromosome
Accession NZ_CP051509
Organism Helicobacter pylori strain ASHA-009

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag HG558_RS01680 Protein ID WP_202166871.1
Coordinates 344312..344593 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag HG558_RS01685 Protein ID WP_202166872.1
Coordinates 344586..344900 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG558_RS01645 339507..339771 + 265 Protein_310 hypothetical protein -
HG558_RS01650 339768..340067 + 300 WP_202166869.1 hypothetical protein -
HG558_RS01655 340067..341008 + 942 Protein_312 Flp pilus assembly complex ATPase component TadA -
HG558_RS01660 341005..341460 + 456 WP_202135313.1 mobilization protein -
HG558_RS01665 341457..341747 + 291 WP_202135314.1 hypothetical protein -
HG558_RS01670 341748..342305 + 558 WP_202135315.1 hypothetical protein -
HG558_RS01675 342306..344033 + 1728 WP_202166870.1 type IV secretory system conjugative DNA transfer family protein -
HG558_RS01680 344312..344593 - 282 WP_202166871.1 YafQ family addiction module toxin Toxin
HG558_RS01685 344586..344900 - 315 WP_202166872.1 hypothetical protein Antitoxin
HG558_RS01690 345192..347099 + 1908 WP_202166873.1 relaxase/mobilization nuclease domain-containing protein -
HG558_RS01695 347124..348286 - 1163 Protein_320 hypothetical protein -
HG558_RS01700 348342..348626 - 285 WP_202166874.1 hypothetical protein -
HG558_RS01705 348698..349354 - 657 WP_202166875.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10875.80 Da        Isoelectric Point: 9.5726

>T154354 WP_202166871.1 NZ_CP051509:c344593-344312 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASVIDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T154354 NZ_CP068029:833161-833523 [Staphylococcus saccharolyticus]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTCCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTTGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACAGTAATTGTTGCTGCAATTACAGGCAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAATACAAATTAGACAAGGACTCCGTTATATTGCTTGAACAGATTAGA
ACATTAGATAAGAAGCGTTTAAAAGAAAAGCTGACTTATTTATCTGAAAGCAAGATGAAAGAAGTTGATAACGCGCTAGA
CATTAGTCTAGGTCTACATAACTTTGATCACCAAAAATCATAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12236.73 Da        Isoelectric Point: 4.9371

>AT154354 WP_202166872.1 NZ_CP051509:c344900-344586 [Helicobacter pylori]
MPNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKYSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERRNA

Download         Length: 315 bp

>AT154354 NZ_CP068029:832994-833164 [Staphylococcus saccharolyticus]
ATGTTATCTTTTAATCAAACTAGAACTAACAGTCTTGAACAATCGTTGAAAGAGGGCTATTCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACGGAAGCTTTTCCTATTGAATGTGAAGCTTGCGATTGTAATGAAACATATTTGACTTCTAATTCAC
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References