Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1019273..1019861 Replicon chromosome
Accession NZ_CP051508
Organism Helicobacter pylori strain ASHA-010

Toxin (Protein)


Gene name TfiT Uniprot ID J0ILK7
Locus tag HG559_RS04860 Protein ID WP_000921935.1
Coordinates 1019273..1019554 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID G2MA82
Locus tag HG559_RS04865 Protein ID WP_000065286.1
Coordinates 1019547..1019861 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG559_RS04825 1014466..1014749 + 284 Protein_941 hypothetical protein -
HG559_RS04830 1014731..1015032 + 302 Protein_942 hypothetical protein -
HG559_RS04835 1015032..1015973 + 942 Protein_943 Flp pilus assembly complex ATPase component TadA -
HG559_RS04840 1015970..1016425 + 456 WP_202135313.1 mobilization protein -
HG559_RS04845 1016422..1016712 + 291 WP_202135314.1 hypothetical protein -
HG559_RS04850 1016713..1017270 + 558 WP_202135315.1 hypothetical protein -
HG559_RS04855 1017271..1018998 + 1728 WP_202165793.1 type IV secretory system conjugative DNA transfer family protein -
HG559_RS04860 1019273..1019554 - 282 WP_000921935.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HG559_RS04865 1019547..1019861 - 315 WP_000065286.1 hypothetical protein Antitoxin
HG559_RS04870 1020153..1020308 + 156 WP_202135317.1 relaxase -
HG559_RS04875 1020325..1020951 + 627 WP_202135318.1 hypothetical protein -
HG559_RS04880 1021008..1021937 - 930 WP_202135319.1 hypothetical protein -
HG559_RS04885 1022171..1023148 + 978 WP_202165795.1 HipA domain-containing protein -
HG559_RS04890 1023320..1023694 + 375 Protein_954 CAAX protease -
HG559_RS04895 1023779..1024003 + 225 WP_202165797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 990130..1049038 58908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10861.77 Da        Isoelectric Point: 9.5726

>T154353 WP_000921935.1 NZ_CP051508:c1019554-1019273 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T154353 NZ_CP068023:3651305-3651955 [Pseudoalteromonas sp. GCY]
GTGGTTTACAACTATAGTCAAACCCTTAACCCACAAAAAGCGTTGATTTGGCGCATAGTGCATCGTAACAATATACCGTG
GATCTTAGATAACGGTTTGTATTGTGGTAATAGTCAGGTGCAGTCACCTAATTGGGAGGCTATAGGTAGTTCGGAGTTAA
TACAAAAACGAGCAACTCATCCTGTCCCGATTGCTCCTTTTGGTTCATTAAATGACTATGTGCCTTTTTACTTTACTCCT
TTCTCACCTATGTTGCTCAACATAAAGTCAGGGCGAGGCGTTATTCAGCGGGCTAACGAAGACATTGTTATTTTGGTATC
ATCATTACATAAAGTTGAACAATTAAACTTGGAATTTGTCTATACGGACATGCATGCCTATTACCTATGGGCTAAATTTT
ATTCTGATTTAAAGCACTTAGGAGCTGTAGATTGGCCTATTTTACAGGCAAGAGATTTTGCTAGAGATCAGAATGATCCC
GCCAAGTTTGAGCGATATCAGGCAGAGGCATTAATCAAACAGCATTGCCCTATCAATGCTTTATTAGGCGTAGTTTGTTA
CAACGCGCAAGTTGAACAACAATTAAAACAGCATATTCAACAGCGCAATATGAATTTGGATGTCATTGTGCGTCCTGGAT
GGTACTTTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12140.62 Da        Isoelectric Point: 5.2248

>AT154353 WP_000065286.1 NZ_CP051508:c1019861-1019547 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERRNA

Download         Length: 315 bp

>AT154353 NZ_CP068023:3651955-3653019 [Pseudoalteromonas sp. GCY]
ATGATCACATATACACAAGGTAATTTACTCGAAGCTAACGCAGATGCTCTAGTCAATACAGTTAATACTGTAGGGGTTAT
GGGTAAAGGCATTGCGTTAATGTTCAAAGAGCGCTTTCCTAAAAACATGGCTGAATATGCAGCTGCCTGCAAGGCTAAGC
GAGTAAACACCGGTCAAATGTTTGTTACTGAAACAGGCGAATTAATGGGACCTAGGTGGATCGTAAACTTCCCTACCAAG
CAGCACTGGCGTGCAAAATCTAAAATGGAATGGATTCAAGATGGTTTAATCGATCTTCGCCACTTTATAGAAAACAATAA
TGTTGGTTCTATAGCAATTCCTCCACTTGGCGCAGGGCAAGGCGGCTTGTCTTGGCCTGACGTAAAACTAGAAATTGAAA
AAGCATTATCCGATATTGAAAATACAAATATCATTGTATTTGAACCTACCAGTAAATATCAAAATGTAGCCAAAAAAGCA
GGTGTAAAGAAACTAACACCAGCGAGAGCTTTAGTTGCCGAGTTAGTAAGACGTTATTGGATATTAGGCATGGAGTGTAG
CCTGCTAGAAATTCAAAAGCTAGCTTGGTTTTTGCAAAGAACCATTGAAAGATCAGGCTTGAAAAATGAGTTAAAGCTTA
ATTTCGAAGCAAATTATTATGGGCCCTATGCCAATAACTTAGAGCACTTGTTAAATGCTTTAGATGGTAGTTATTTGAAA
TCAGATAAACGTATTCCTGATTGTGATCCTTTAGATGTCATCTGGTTCAATGAAAACGAGAGACAAAAAGTTTCGACCTA
CTTAAGCACCGAGGCGAAAGAGTATTTACCTGCATTAGAAGAAGCAACTCAAGTAATTAATGGCTTCGAATCTCCTTTTG
GCTTAGAGCTTTTGTCTACAGTGGATTGGCTTATTACTAAGCAAGGATGTGATAAAACGGTTGAGTCAATAAAAGAAGGC
ATAGCCAACTGGCCTACTGGAGATAAATGGGCACTGCGCAAGTTAACCTTATTTGGCGATAGAGAAATTCAATTTGCTTT
GACTAATTTGGAAAACCTACATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0PNN7

Antitoxin

Source ID Structure
AlphaFold DB G2MA82

References