Detailed information of TA system TA154342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 218007..218595
• Replicon: chromosome
• Accession: NZ_CP051503
• Organism: Helicobacter pylori strain SHIM-014

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: M3P300
• Locus tag: HG564_RS01080
• Protein ID: WP_000921941.1
• Coordinates: 218007..218288 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HG564_RS01085
• Protein ID: WP_000065282.1
• Coordinates: 218281..218595 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG564_RS01045	213207..213470	+	264	WP_000564645.1	hypothetical protein	-
HG564_RS01050	213467..213766	+	300	WP_202171954.1	hypothetical protein	-
HG564_RS01055	213766..214707	+	942	WP_000625128.1	Flp pilus assembly complex ATPase component TadA	-
HG564_RS01060	214704..215159	+	456	WP_000795438.1	hypothetical protein	-
HG564_RS01065	215156..215446	+	291	WP_000159821.1	hypothetical protein	-
HG564_RS01070	215447..216004	+	558	WP_001167785.1	hypothetical protein	-
HG564_RS01075	216005..217732	+	1728	WP_001208196.1	type IV secretory system conjugative DNA transfer family protein	-
HG564_RS01080	218007..218288	-	282	WP_000921941.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HG564_RS01085	218281..218595	-	315	WP_000065282.1	hypothetical protein	Antitoxin
HG564_RS01090	218858..220763	+	1906	Protein_209	relaxase/mobilization nuclease domain-containing protein	-
HG564_RS01095	220788..221972	-	1185	WP_202171955.1	hypothetical protein	-
HG564_RS01100	222004..222273	-	270	WP_000394629.1	hypothetical protein	-
HG564_RS01105	222358..223014	-	657	WP_000587369.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10891.80 Da
• Isoelectric Point: 9.5726

>T154342 WP_000921941.1 NZ_CP051503:c218288-218007 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T154342 NZ_CP068018:c4427685-4427410 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12126.64 Da
• Isoelectric Point: 5.2248

>AT154342 WP_000065282.1 NZ_CP051503:c218595-218281 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKKKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDNPE
CDVSFGDFNDFLQIAKQERERQDA

Nucleotide

• Length: 315 bp

>AT154342 NZ_CP068018:c4427948-4427688 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: M3P300