Detailed information of TA system TA154337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 874847..875435
• Replicon: chromosome
• Accession: NZ_CP051500
• Organism: Helicobacter pylori strain PUNO-003

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: T5CGR9
• Locus tag: HG567_RS04060
• Protein ID: WP_000921933.1
• Coordinates: 875154..875435 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HG567_RS04055
• Protein ID: WP_108339294.1
• Coordinates: 874847..875161 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG567_RS04035	870366..871022	+	657	WP_202139280.1	ParA family protein	-
HG567_RS04040	871106..871390	+	285	WP_000394651.1	hypothetical protein	-
HG567_RS04045	871434..872612	+	1179	WP_202163660.1	hypothetical protein	-
HG567_RS04050	872637..874550	-	1914	WP_202139282.1	relaxase/mobilization nuclease domain-containing protein	-
HG567_RS04055	874847..875161	+	315	WP_108339294.1	hypothetical protein	Antitoxin
HG567_RS04060	875154..875435	+	282	WP_000921933.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HG567_RS04065	875710..877438	-	1729	Protein_795	type IV secretory system conjugative DNA transfer family protein	-
HG567_RS04070	877439..877996	-	558	WP_001167786.1	hypothetical protein	-
HG567_RS04075	877997..878287	-	291	WP_202139283.1	hypothetical protein	-
HG567_RS04080	878284..878739	-	456	WP_202139284.1	mobilization protein	-
HG567_RS04085	878736..879677	-	942	WP_078216366.1	Flp pilus assembly complex ATPase component TadA	-
HG567_RS04090	879677..879976	-	300	WP_202139285.1	hypothetical protein	-
HG567_RS04095	879973..880236	-	264	WP_202139286.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10875.80 Da
• Isoelectric Point: 9.5726

>T154337 WP_000921933.1 NZ_CP051500:875154-875435 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T154337 NZ_CP068018:c2293518-2293234 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12250.68 Da
• Isoelectric Point: 5.2068

>AT154337 WP_108339294.1 NZ_CP051500:874847-875161 [Helicobacter pylori]
MPNVITDYSQYNEKQLQHFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTINSKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT154337 NZ_CP068018:c2293756-2293508 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: T5CGR9