Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1162767..1163355 Replicon chromosome
Accession NZ_CP051497
Organism Helicobacter pylori strain PUNO-007

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag HG570_RS05420 Protein ID WP_088297872.1
Coordinates 1162767..1163048 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag HG570_RS05425 Protein ID WP_079359914.1
Coordinates 1163041..1163355 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG570_RS05385 1157974..1158237 + 264 WP_202141451.1 hypothetical protein -
HG570_RS05390 1158234..1158533 + 300 WP_121086536.1 hypothetical protein -
HG570_RS05395 1158533..1159474 + 942 WP_202141452.1 Flp pilus assembly complex ATPase component TadA -
HG570_RS05400 1159471..1159926 + 456 WP_000795426.1 hypothetical protein -
HG570_RS05405 1159923..1160213 + 291 WP_000159813.1 hypothetical protein -
HG570_RS05410 1160214..1160771 + 558 WP_202141453.1 hypothetical protein -
HG570_RS05415 1160772..1162520 + 1749 WP_202141454.1 type IV secretory system conjugative DNA transfer family protein -
HG570_RS05420 1162767..1163048 - 282 WP_088297872.1 YafQ family addiction module toxin Toxin
HG570_RS05425 1163041..1163355 - 315 WP_079359914.1 hypothetical protein Antitoxin
HG570_RS05430 1163659..1165572 + 1914 WP_202141455.1 relaxase/mobilization nuclease domain-containing protein -
HG570_RS05435 1165597..1166769 - 1173 WP_202141456.1 hypothetical protein -
HG570_RS05440 1166813..1167094 - 282 WP_202141457.1 hypothetical protein -
HG570_RS05445 1167179..1167835 - 657 WP_202141458.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flgK / flgM / gluP 1080766..1207053 126287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10888.84 Da        Isoelectric Point: 9.8257

>T154334 WP_088297872.1 NZ_CP051497:c1163048-1162767 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T154334 NZ_CP068018:583702-583989 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12093.52 Da        Isoelectric Point: 4.9439

>AT154334 WP_079359914.1 NZ_CP051497:c1163355-1163041 [Helicobacter pylori]
MSNVITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHDA

Download         Length: 315 bp

>AT154334 NZ_CP068018:583976-584278 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References