Detailed information of TA system TA154333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 1045945..1046533
• Replicon: chromosome
• Accession: NZ_CP051496
• Organism: Helicobacter pylori strain PUNO-008

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: J0ILK7
• Locus tag: HG571_RS04920
• Protein ID: WP_000921935.1
• Coordinates: 1046252..1046533 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HG571_RS04915
• Protein ID: WP_000065287.1
• Coordinates: 1045945..1046259 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG571_RS04895	1041483..1042139	+	657	WP_202140388.1	ParA family protein	-
HG571_RS04900	1042224..1042508	+	285	WP_000394655.1	hypothetical protein	-
HG571_RS04905	1042552..1043724	+	1173	WP_202140389.1	hypothetical protein	-
HG571_RS04910	1043749..1045660	-	1912	Protein_958	relaxase/mobilization nuclease domain-containing protein	-
HG571_RS04915	1045945..1046259	+	315	WP_000065287.1	hypothetical protein	Antitoxin
HG571_RS04920	1046252..1046533	+	282	WP_000921935.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HG571_RS04925	1046808..1048535	-	1728	WP_202140390.1	type IV secretory system conjugative DNA transfer family protein	-
HG571_RS04930	1048536..1049093	-	558	WP_202140391.1	hypothetical protein	-
HG571_RS04935	1049094..1049384	-	291	WP_202140392.1	hypothetical protein	-
HG571_RS04940	1049381..1049836	-	456	WP_202140393.1	mobilization protein	-
HG571_RS04945	1049833..1050774	-	942	WP_000625128.1	Flp pilus assembly complex ATPase component TadA	-
HG571_RS04950	1050774..1051073	-	300	WP_000660135.1	hypothetical protein	-
HG571_RS04955	1051070..1051333	-	264	WP_000564647.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10861.77 Da
• Isoelectric Point: 9.5726

>T154333 WP_000921935.1 NZ_CP051496:1046252-1046533 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T154333 NZ_CP068018:489733-490017 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12200.66 Da
• Isoelectric Point: 5.2250

>AT154333 WP_000065287.1 NZ_CP051496:1045945-1046259 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERRNA

Nucleotide

• Length: 315 bp

>AT154333 NZ_CP068018:489501-489743 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0L0PNN7