Detailed information of TA system TA154291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 191283..191788
• Replicon: chromosome
• Accession: NZ_CP051488
• Organism: Kosakonia sp. SMBL-WEM22

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HF650_RS00965
• Protein ID: WP_054802690.1
• Coordinates: 191528..191788 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HF650_RS00960
• Protein ID: WP_187802570.1
• Coordinates: 191283..191531 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF650_RS00940	187781..188227	-	447	WP_187800807.1	N-acetyltransferase	-
HF650_RS00945	188208..188786	-	579	WP_187800808.1	DNA-3-methyladenine glycosylase I	-
HF650_RS00950	188934..189614	+	681	WP_187800809.1	autotransporter domain-containing protein	-
HF650_RS00955	189856..191058	+	1203	WP_187800810.1	MFS transporter	-
HF650_RS00960	191283..191531	+	249	WP_187802570.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HF650_RS00965	191528..191788	+	261	WP_054802690.1	Txe/YoeB family addiction module toxin	Toxin
HF650_RS00970	191892..192323	+	432	WP_187800811.1	organic hydroperoxide resistance protein	-
HF650_RS00975	192536..194218	+	1683	WP_187800812.1	kdo(2)-lipid A phosphoethanolamine 7''-transferase	-
HF650_RS00990	194550..194750	-	201	WP_187800813.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10250.87 Da
• Isoelectric Point: 9.7713

>T154291 WP_054802690.1 NZ_CP051488:191528-191788 [Kosakonia sp. SMBL-WEM22]
MTPRITPEAQADIDFWKQNDPKVKQKIDTLVRDALEHPFQGLGKPEALKHHKPLWSRRITKEHRLVYYIKDDSLIIVSCR
YHYVNL

Nucleotide

• Length: 261 bp

>T154291 NZ_CP067993:259354-259641 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCCGGAGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCGGGTTACCGCGTGTACTACACCCAGCGCGGCAGGCAGTTGGTGATTCTCCTGGTTGGAGGCGACAAGGGTTCA
CAGCAGCGCGATATCGAGAAGGCCAGGGAGATTGCGCGTGCCCTGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9190.22 Da
• Isoelectric Point: 4.3588

>AT154291 WP_187802570.1 NZ_CP051488:191283-191531 [Kosakonia sp. SMBL-WEM22]
MQHVNYTDARQNLASLMQQANDELAPILVTRKGAKSVVVIDAEEFASMQETLHLFSNPVNAAHIERSIQQAESGDLQEYT
FE

Nucleotide

• Length: 249 bp

>AT154291 NZ_CP067993:259700-260002 [Stenotrophomonas maltophilia]
ATGGCCATCAAGAGAAAAGTCGAACTCAAATCATTTGATGTGGCCGAGCATCTTCGGACGCCGGAGGAGATGGCGGCTTA
TCTCGACGCCTGCATCGAAGAAAGCGACGGTGATTCTGCATTTATCGCCAAGGCGCTCGGCGATATCGCTCGCGCTCAGG
GCATGAGCAAGGTTGCGCGTGCGGCGGGCTTGTCGCGTGAGAGTCTGTATCGCGCACTGTCGGGCGAGCGCAGTCCGGAT
TTCGCGACCATCCTGAAGGTGACCCGGGCCCTGGGTGTGCGATTGCACGCCAGCGCTGTGTAA