Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 49987..50694 | Replicon | chromosome |
Accession | NZ_CP051488 | ||
Organism | Kosakonia sp. SMBL-WEM22 |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | - |
Locus tag | HF650_RS00245 | Protein ID | WP_076769309.1 |
Coordinates | 50389..50694 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | - |
Locus tag | HF650_RS00240 | Protein ID | WP_094422700.1 |
Coordinates | 49987..50388 (-) | Length | 134 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF650_RS00220 | 45764..46711 | + | 948 | WP_187800709.1 | ABC transporter permease | - |
HF650_RS00225 | 46708..47691 | + | 984 | WP_139966572.1 | ABC transporter ATP-binding protein | - |
HF650_RS00230 | 47688..48662 | + | 975 | WP_187800710.1 | ATP-binding cassette domain-containing protein | - |
HF650_RS00235 | 48736..49929 | + | 1194 | WP_187800711.1 | glutathione-dependent formaldehyde dehydrogenase | - |
HF650_RS00240 | 49987..50388 | - | 402 | WP_094422700.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
HF650_RS00245 | 50389..50694 | - | 306 | WP_076769309.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
HF650_RS00250 | 50852..51505 | - | 654 | WP_187800712.1 | oxygen-insensitive NAD(P)H nitroreductase | - |
HF650_RS00255 | 51701..52636 | + | 936 | WP_187802558.1 | LysR family transcriptional regulator | - |
HF650_RS00260 | 52698..53651 | + | 954 | WP_187800713.1 | aldo/keto reductase | - |
HF650_RS00265 | 53761..54171 | + | 411 | WP_187800714.1 | DUF1311 domain-containing protein | - |
HF650_RS00270 | 54251..55423 | - | 1173 | WP_187800715.1 | multidrug effflux MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11603.59 Da Isoelectric Point: 8.9492
>T154290 WP_076769309.1 NZ_CP051488:c50694-50389 [Kosakonia sp. SMBL-WEM22]
MEKGTPHVRLHIVKRMVLEGKVRTTASAVAGAIELGFNPPPFDEMCAVIQALTSEDFFKSMTAYVDHTVWHDVYRPVWKR
QKLYLKLIVSDDVLIVSFKER
MEKGTPHVRLHIVKRMVLEGKVRTTASAVAGAIELGFNPPPFDEMCAVIQALTSEDFFKSMTAYVDHTVWHDVYRPVWKR
QKLYLKLIVSDDVLIVSFKER
Download Length: 306 bp
>T154290 NZ_CP067993:c104943-103621 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTCGAGGTCGCGCTCTGGGATGATGTCCGGAGCGGCTCTTCCCGGCTTTC
GTACGTCGACTCGTGGATCAGCTCCGCCCAGTCCCGGCCGTTGTCACTCTCACTGCCCCTGCTCCCGGAGGGTGAGAGCC
ATCGGGGCGATGTCGTCAACAACTACTTCGACAACCTTCTTCCCGACAACGCCGTCATCCGCAACCGGATCCGCGACAGG
TTCTCCACGCGCAGCAGCGACACATTCGATCTTCTCGAAGCCATTGGCCGGGATTGCGTCGGCGCAGTGCAACTGCTGCC
GCTTTCGCATACACCGGGGAACATCCAGCAGATTACGTGCGAAGCGTTGGACGAATCAGGCGTCGCTGCGATCCTGCGTC
AGGTGACGGCAGGGAATCTACCTGGCGCACCCACCAGTGATGATGCGTTCCGCATATCCATCGCCGGTGCGCAGGAGAAG
ACGGGACTTCTGCTGCATGCTGGCCAGTGGTGCATTCCTACCGGCAGTACCCCATCCACCCATATCTTCAAGCTGCCGCT
TGGCATTGTGGGCAACATGCGGGCGGACATGCACCAATCCGTCGAGAACGAATGGCTTTGCATGCAACTGCTTTCCGCCT
TTGGAATCCCCGTTGCGAATACGCAGATGGGACGCTTCAAGGACGAACGCGCGCTTATTGTGGAGCGATTCGACCGCCGC
CTTTCTGCGGATCGCCGGTGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTCGGTCTGCCCGCTGCCAGGAA
GTATGAATCCGATGGCGGCCCAGGCATCGTGACCATCATGGATCTGCTTCGACAATCCGAGCATTTCGAGGATCGGGCGA
CCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGACATGCCAAGAACTTCAGTGTTTACCTCGAA
GCCGGTGGACGCTTCCGCCTGACACCCGTCTACGACGTATTGTCGGTGCATCCCATCCTGGGTAGGGGGCCAAACCAGCT
CGACCCGCGAAATGCACAGCTCGCCATGTCCGTCCAGGGCAAGAACCGCCACCGGAAGCTGCACCTTGTGCGACGACGCC
ATTGGAACGAAACCGCACGCGCCTGTGGTGTCGCTGATGGTGCGGAGCCGTGGATCGAAGCGCTGATCGCAGCCGTCGAA
CCCGCCATCGAGCAGGTCACGCGTCAGCTCCCAAGTGATTTCCCCGTAAACGTGTCCGAACCCATTTTCAACGGGCTGCG
CGCTGCGGCGGCACGCCTTTCCAGCATGTCGCCGGACGCCTGA
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTCGAGGTCGCGCTCTGGGATGATGTCCGGAGCGGCTCTTCCCGGCTTTC
GTACGTCGACTCGTGGATCAGCTCCGCCCAGTCCCGGCCGTTGTCACTCTCACTGCCCCTGCTCCCGGAGGGTGAGAGCC
ATCGGGGCGATGTCGTCAACAACTACTTCGACAACCTTCTTCCCGACAACGCCGTCATCCGCAACCGGATCCGCGACAGG
TTCTCCACGCGCAGCAGCGACACATTCGATCTTCTCGAAGCCATTGGCCGGGATTGCGTCGGCGCAGTGCAACTGCTGCC
GCTTTCGCATACACCGGGGAACATCCAGCAGATTACGTGCGAAGCGTTGGACGAATCAGGCGTCGCTGCGATCCTGCGTC
AGGTGACGGCAGGGAATCTACCTGGCGCACCCACCAGTGATGATGCGTTCCGCATATCCATCGCCGGTGCGCAGGAGAAG
ACGGGACTTCTGCTGCATGCTGGCCAGTGGTGCATTCCTACCGGCAGTACCCCATCCACCCATATCTTCAAGCTGCCGCT
TGGCATTGTGGGCAACATGCGGGCGGACATGCACCAATCCGTCGAGAACGAATGGCTTTGCATGCAACTGCTTTCCGCCT
TTGGAATCCCCGTTGCGAATACGCAGATGGGACGCTTCAAGGACGAACGCGCGCTTATTGTGGAGCGATTCGACCGCCGC
CTTTCTGCGGATCGCCGGTGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTCGGTCTGCCCGCTGCCAGGAA
GTATGAATCCGATGGCGGCCCAGGCATCGTGACCATCATGGATCTGCTTCGACAATCCGAGCATTTCGAGGATCGGGCGA
CCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGACATGCCAAGAACTTCAGTGTTTACCTCGAA
GCCGGTGGACGCTTCCGCCTGACACCCGTCTACGACGTATTGTCGGTGCATCCCATCCTGGGTAGGGGGCCAAACCAGCT
CGACCCGCGAAATGCACAGCTCGCCATGTCCGTCCAGGGCAAGAACCGCCACCGGAAGCTGCACCTTGTGCGACGACGCC
ATTGGAACGAAACCGCACGCGCCTGTGGTGTCGCTGATGGTGCGGAGCCGTGGATCGAAGCGCTGATCGCAGCCGTCGAA
CCCGCCATCGAGCAGGTCACGCGTCAGCTCCCAAGTGATTTCCCCGTAAACGTGTCCGAACCCATTTTCAACGGGCTGCG
CGCTGCGGCGGCACGCCTTTCCAGCATGTCGCCGGACGCCTGA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14965.20 Da Isoelectric Point: 8.4709
>AT154290 WP_094422700.1 NZ_CP051488:c50388-49987 [Kosakonia sp. SMBL-WEM22]
MKCPVCGAAGLKYDTRNIEYRYKGKVTTLTAITGDYCDACGEIIFDRLNGELYSKQVAAFVRKVNAEEVDPQFIATIRKR
FNLDQRQAAEMFGGGANAFSRYETGRVAPPRPLVLLFKALDKHPELFEELKHA
MKCPVCGAAGLKYDTRNIEYRYKGKVTTLTAITGDYCDACGEIIFDRLNGELYSKQVAAFVRKVNAEEVDPQFIATIRKR
FNLDQRQAAEMFGGGANAFSRYETGRVAPPRPLVLLFKALDKHPELFEELKHA
Download Length: 402 bp
>AT154290 NZ_CP067993:c105204-104947 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACGGTGAGGACACCTCAACAACTGGCACCGCTGATGCGTGCGTTCAGGCGCCAGGCGGGCCT
GAGCCAGGCGCAGTTGGCGGCACAGCTCGGCATAAGCCGCCAGGCAGTAGGCGCATTGGAGCGCGACCCGGCATCGGCAA
GCTTCGAACGGCTGATGCGGGTCTGGGCAGTGCTGGGTCTGGAAGTCAGATTGCAGCAGCGAAGCCCCCCGGAGACAACG
TCAACGTTGGAGTGGTGA
ATGGACAGGCCGCTGCACACGGTGAGGACACCTCAACAACTGGCACCGCTGATGCGTGCGTTCAGGCGCCAGGCGGGCCT
GAGCCAGGCGCAGTTGGCGGCACAGCTCGGCATAAGCCGCCAGGCAGTAGGCGCATTGGAGCGCGACCCGGCATCGGCAA
GCTTCGAACGGCTGATGCGGGTCTGGGCAGTGCTGGGTCTGGAAGTCAGATTGCAGCAGCGAAGCCCCCCGGAGACAACG
TCAACGTTGGAGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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