Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1823128..1823651 Replicon chromosome
Accession NZ_CP051484
Organism Staphylococcus aureus strain NGA71

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HGO96_RS09070 Protein ID WP_054189905.1
Coordinates 1823128..1823394 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HGO96_RS09075 Protein ID WP_020977565.1
Coordinates 1823394..1823651 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO96_RS09050 (1818337) 1818337..1819524 - 1188 WP_054189907.1 MFS transporter -
HGO96_RS09055 (1819917) 1819917..1820693 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
HGO96_RS09060 (1820686) 1820686..1821348 - 663 WP_025786559.1 ATP-binding cassette domain-containing protein -
HGO96_RS09065 (1821698) 1821698..1822774 - 1077 WP_054189906.1 M42 family metallopeptidase -
HGO96_RS09070 (1823128) 1823128..1823394 - 267 WP_054189905.1 Txe/YoeB family addiction module toxin Toxin
HGO96_RS09075 (1823394) 1823394..1823651 - 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGO96_RS09080 (1824011) 1824011..1824466 + 456 WP_000732082.1 DUF1307 domain-containing protein -
HGO96_RS09085 (1824634) 1824634..1826211 - 1578 WP_054189904.1 FMN-binding glutamate synthase family protein -
HGO96_RS09090 (1826406) 1826406..1827155 + 750 WP_054189903.1 CPBP family lipoprotein N-acylation protein LnsB -
HGO96_RS09095 (1827379) 1827379..1828572 - 1194 WP_006191034.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10587.19 Da        Isoelectric Point: 10.1603

>T154285 WP_054189905.1 NZ_CP051484:c1823394-1823128 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKITHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRGVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T154285 NZ_CP067966:4308614-4308982 [Klebsiella quasipneumoniae]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGACATGCTTATCACCCGTGGTTGTCTGGCAAATGCTGCTTGC
TCGACTACTTGAGCAGCACTATGGCCTGACCTTAAATGACACGCCGTTCAGCGATGAGGCTGTTATTAAAAGACATATCG
AAGCTGGTATCACGCTTGTCGATGCCGTTAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACCGCAGAGGATTT
AGCTCACAGGGACCAGTGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGTGGATTAACGAACAGTTG
TCCTTATCGGGAAGTAAGTAATATTGTTCTTGGCCGATCGCGGCAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT154285 WP_020977565.1 NZ_CP051484:c1823651-1823394 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT154285 NZ_CP067966:4308229-4308579 [Klebsiella quasipneumoniae]
ATGTCGAGTAAGACACTCACAGTGAATGATGATACCGCTGAGCCCTGGTGGGGGCTGAATCGTAATGTCATTCCTTGTTT
TGGTGCGCGTCTGGTCCAGGAAGGTAACCGCCTATATTACCTGTCTGACCGCGCCAGCATAATAGGCCTATTCAATAAAG
CGGATTTGCTCCGTCTTGACCAGGCATTTCCTGTTCTGCTGAAGCAGGCGGAGCTCATGCTTACCAGCGGCGAACTGAAT
CCCCGACACCAGCATTGCGTCACCCTCTATGCAAAGGGGCTGACCTGCGAAGCTGATACGCTGGGTTCCTGTGGTCACGT
CTATATCTCCATTTATCCTACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References