Detailed information of TA system TA154282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1770897..1771414
• Replicon: chromosome
• Accession: NZ_CP051484
• Organism: Staphylococcus aureus strain NGA71

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HGO96_RS08805
• Protein ID: WP_153145606.1
• Coordinates: 1770897..1771163 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HGO96_RS08810
• Protein ID: WP_054189941.1
• Coordinates: 1771163..1771414 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO96_RS08775 (1766102)	1766102..1766638	-	537	WP_054189946.1	GNAT family N-acetyltransferase	-
HGO96_RS08780 (1767107)	1767107..1767931	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
HGO96_RS08785 (1768134)	1768134..1768316	-	183	WP_054189945.1	hypothetical protein	-
HGO96_RS08790 (1768403)	1768403..1768870	-	468	WP_054189944.1	SRPBCC domain-containing protein	-
HGO96_RS08795 (1769056)	1769056..1770603	-	1548	WP_054189943.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
HGO96_RS08800 (1770791)	1770791..1770862	-	72	WP_223200558.1	hypothetical protein	-
HGO96_RS08805 (1770897)	1770897..1771163	-	267	WP_153145606.1	Txe/YoeB family addiction module toxin	Toxin
HGO96_RS08810 (1771163)	1771163..1771414	-	252	WP_054189941.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HGO96_RS08815 (1771579)	1771579..1771680	-	102	Protein_1703	hypothetical protein	-
HGO96_RS08820 (1771687)	1771687..1772286	-	600	WP_054189940.1	DsbA family protein	-
HGO96_RS08825 (1772305)	1772305..1772667	-	363	WP_054189939.1	DUF4467 domain-containing protein	-
HGO96_RS08830 (1772923)	1772923..1774173	+	1251	WP_054189938.1	FemA/FemB family glycyltransferase FmhA	-
HGO96_RS08835 (1774268)	1774268..1774999	-	732	WP_054189937.1	amino acid ABC transporter ATP-binding protein	-
HGO96_RS08840 (1774996)	1774996..1775715	-	720	WP_054189936.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10424.03 Da
• Isoelectric Point: 10.0573

>T154282 WP_153145606.1 NZ_CP051484:c1771163-1770897 [Staphylococcus aureus]
MARLNIMFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T154282 NZ_CP067966:1910135-1910237 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.69 Da
• Isoelectric Point: 4.3407

>AT154282 WP_054189941.1 NZ_CP051484:c1771414-1771163 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Nucleotide

• Length: 252 bp

>AT154282 NZ_CP067966:c1910241-1910094 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG