Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1770897..1771414 Replicon chromosome
Accession NZ_CP051484
Organism Staphylococcus aureus strain NGA71

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HGO96_RS08805 Protein ID WP_153145606.1
Coordinates 1770897..1771163 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HGO96_RS08810 Protein ID WP_054189941.1
Coordinates 1771163..1771414 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO96_RS08775 (1766102) 1766102..1766638 - 537 WP_054189946.1 GNAT family N-acetyltransferase -
HGO96_RS08780 (1767107) 1767107..1767931 - 825 WP_000594640.1 formate/nitrite transporter family protein -
HGO96_RS08785 (1768134) 1768134..1768316 - 183 WP_054189945.1 hypothetical protein -
HGO96_RS08790 (1768403) 1768403..1768870 - 468 WP_054189944.1 SRPBCC domain-containing protein -
HGO96_RS08795 (1769056) 1769056..1770603 - 1548 WP_054189943.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HGO96_RS08800 (1770791) 1770791..1770862 - 72 WP_223200558.1 hypothetical protein -
HGO96_RS08805 (1770897) 1770897..1771163 - 267 WP_153145606.1 Txe/YoeB family addiction module toxin Toxin
HGO96_RS08810 (1771163) 1771163..1771414 - 252 WP_054189941.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGO96_RS08815 (1771579) 1771579..1771680 - 102 Protein_1703 hypothetical protein -
HGO96_RS08820 (1771687) 1771687..1772286 - 600 WP_054189940.1 DsbA family protein -
HGO96_RS08825 (1772305) 1772305..1772667 - 363 WP_054189939.1 DUF4467 domain-containing protein -
HGO96_RS08830 (1772923) 1772923..1774173 + 1251 WP_054189938.1 FemA/FemB family glycyltransferase FmhA -
HGO96_RS08835 (1774268) 1774268..1774999 - 732 WP_054189937.1 amino acid ABC transporter ATP-binding protein -
HGO96_RS08840 (1774996) 1774996..1775715 - 720 WP_054189936.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10424.03 Da        Isoelectric Point: 10.0573

>T154282 WP_153145606.1 NZ_CP051484:c1771163-1770897 [Staphylococcus aureus]
MARLNIMFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T154282 NZ_CP067966:1910135-1910237 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.69 Da        Isoelectric Point: 4.3407

>AT154282 WP_054189941.1 NZ_CP051484:c1771414-1771163 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Download         Length: 252 bp

>AT154282 NZ_CP067966:c1910241-1910094 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References