Detailed information of TA system TA154277

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1215586..1215766
• Replicon: chromosome
• Accession: NZ_CP051484
• Organism: Staphylococcus aureus strain NGA71

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HGO96_RS05870
• Protein ID: WP_001801861.1
• Coordinates: 1215586..1215681 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1215709..1215766 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO96_RS05845	1210987..1211613	+	627	WP_054190584.1	hypothetical protein	-
HGO96_RS05850	1211654..1211995	+	342	WP_054190585.1	DUF3969 family protein	-
HGO96_RS05855	1212096..1212668	+	573	WP_054190586.1	hypothetical protein	-
HGO96_RS05860	1213045..1213881	+	837	WP_054190587.1	ATP-binding cassette domain-containing protein	-
HGO96_RS05865	1214688..1215134	-	447	WP_054190589.1	DUF1433 domain-containing protein	-
HGO96_RS05870	1215586..1215681	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1215709..1215766	-	58	-	-	Antitoxin
HGO96_RS05875	1215804..1215905	+	102	WP_054190590.1	hypothetical protein	-
HGO96_RS05880	1215891..1216158	-	268	Protein_1168	transposase	-
HGO96_RS05885	1216190..1216552	+	363	WP_054190591.1	colicin E3/pyocin S6 family cytotoxin	-
HGO96_RS05890	1216574..1217077	+	504	WP_054190592.1	hypothetical protein	-
HGO96_RS05895	1217632..1218075	-	444	WP_054190593.1	DUF1433 domain-containing protein	-
HGO96_RS05900	1218075..1218518	-	444	WP_054190594.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T154277 WP_001801861.1 NZ_CP051484:1215586-1215681 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T154277 NZ_CP067431:19780-20085 [Escherichia coli O22:H8]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT154277 NZ_CP051484:c1215766-1215709 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin