Detailed information of TA system TA154273

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 886419..886998
• Replicon: chromosome
• Accession: NZ_CP051484
• Organism: Staphylococcus aureus strain NGA71

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HGO96_RS04260
• Protein ID: WP_001025401.1
• Coordinates: 886753..886998 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	886419..886784 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO96_RS04220 (883162)	883162..883719	-	558	WP_000645042.1	DUF2815 family protein	-
HGO96_RS04225 (883745)	883745..884911	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
HGO96_RS04230 (884908)	884908..885270	-	363	WP_000985984.1	hypothetical protein	-
HGO96_RS04235 (885285)	885285..885608	-	324	WP_000175001.1	hypothetical protein	-
HGO96_RS04240 (885687)	885687..885848	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
HGO96_RS04245 (885861)	885861..886124	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
HGO96_RS04250 (886149)	886149..886364	-	216	WP_001097552.1	hypothetical protein	-
HGO96_RS04255 (886419)	886419..886784	+	366	WP_001128433.1	hypothetical protein	Antitoxin
HGO96_RS04260 (886753)	886753..886998	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HGO96_RS04265 (887054)	887054..887263	+	210	WP_000642492.1	hypothetical protein	-
HGO96_RS04270 (887253)	887253..887396	-	144	WP_000939498.1	hypothetical protein	-
HGO96_RS04275 (887425)	887425..888201	-	777	WP_001148544.1	Rha family transcriptional regulator	-
HGO96_RS04280 (888215)	888215..888451	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
HGO96_RS04285 (888603)	888603..888917	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
HGO96_RS04290 (888930)	888930..889391	+	462	WP_000525004.1	hypothetical protein	-
HGO96_RS04295 (889409)	889409..889843	+	435	WP_000755718.1	hypothetical protein	-
HGO96_RS04300 (889872)	889872..890267	+	396	WP_000449655.1	hypothetical protein	-
HGO96_RS04305 (890357)	890357..890503	+	147	WP_001795334.1	hypothetical protein	-
HGO96_RS04310 (890500)	890500..891114	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	841227..910083	68856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T154273 WP_001025401.1 NZ_CP051484:c886998-886753 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T154273 NZ_CP067426:c5092017-5091844 [Escherichia coli O22:H8]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT154273 NZ_CP051484:886419-886784 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin