Detailed information of TA system TA154268

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18833..19171
• Replicon: chromosome
• Accession: NZ_CP051484
• Organism: Staphylococcus aureus strain NGA71

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: HGO96_RS00105
• Protein ID: WP_077446684.1
• Coordinates: 18833..19009 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	18997..19171 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO96_RS00085	14066..17851	+	3786	WP_000582158.1	phage tail spike protein	-
HGO96_RS00090	17841..17993	+	153	WP_001153681.1	hypothetical protein	-
HGO96_RS00095	18040..18327	+	288	WP_001040261.1	hypothetical protein	-
HGO96_RS00100	18385..18681	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
HGO96_RS00105	18833..19009	+	177	WP_077446684.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	18997..19171	-	175	-	-	Antitoxin
HGO96_RS00115	19221..19475	+	255	WP_000611512.1	phage holin	-
HGO96_RS00120	19487..20242	+	756	WP_000861038.1	CHAP domain-containing protein	-
HGO96_RS00125	20433..20924	+	492	WP_000919350.1	staphylokinase	-
HGO96_RS00130	21574..21909	+	336	Protein_25	SH3 domain-containing protein	-
HGO96_RS00135	22418..22768	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
HGO96_RS00140	22821..23081	-	261	WP_001791826.1	hypothetical protein	-
HGO96_RS00145	23392..23571	-	180	WP_000669789.1	hypothetical protein	-
HGO96_RS00150	23999..24091	+	93	WP_001788321.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..42114	42113

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6844.44 Da
• Isoelectric Point: 9.9479

>T154268 WP_077446684.1 NZ_CP051484:18833-19009 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKFIELSNKK

Nucleotide

• Length: 177 bp

>T154268 NZ_CP067426:4027504-4027722 [Escherichia coli O22:H8]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT154268 NZ_CP051484:c19171-18997 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin