154261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2392071..2392588 Replicon chromosome
Accession NZ_CP051483
Organism Staphylococcus aureus strain NGA66a

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HGO94_RS11730 Protein ID WP_000113262.1
Coordinates 2392322..2392588 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HGO94_RS11725 Protein ID WP_000584499.1
Coordinates 2392071..2392322 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO94_RS11695 (2387769) 2387769..2388488 + 720 WP_000479576.1 amino acid ABC transporter permease -
HGO94_RS11700 (2388485) 2388485..2389216 + 732 WP_000615458.1 ATP-binding cassette domain-containing protein -
HGO94_RS11705 (2389313) 2389313..2390563 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
HGO94_RS11710 (2390818) 2390818..2391180 + 363 WP_000819843.1 DUF4467 domain-containing protein -
HGO94_RS11715 (2391199) 2391199..2391798 + 600 WP_000162810.1 DsbA family protein -
HGO94_RS11720 (2391826) 2391826..2391906 + 81 WP_223197974.1 hypothetical protein -
HGO94_RS11725 (2392071) 2392071..2392322 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGO94_RS11730 (2392322) 2392322..2392588 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HGO94_RS11735 (2392623) 2392623..2392694 + 72 WP_223200558.1 hypothetical protein -
HGO94_RS11740 (2392882) 2392882..2394432 + 1551 WP_054193111.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HGO94_RS11745 (2394618) 2394618..2395085 + 468 WP_000153344.1 SRPBCC domain-containing protein -
HGO94_RS11750 (2395169) 2395169..2395351 + 183 WP_000230294.1 hypothetical protein -
HGO94_RS11755 (2395568) 2395568..2396392 + 825 WP_000572040.1 formate/nitrite transporter family protein -
HGO94_RS11760 (2396636) 2396636..2397163 + 528 WP_000973468.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T154261 WP_000113262.1 NZ_CP051483:2392322-2392588 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T154261 NZ_CP067426:2384430-2384533 [Escherichia coli O22:H8]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT154261 WP_000584499.1 NZ_CP051483:2392071-2392322 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT154261 NZ_CP067426:c2384571-2384300 [Escherichia coli O22:H8]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References