Detailed information of TA system TA154259

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2367115..2367299
• Replicon: chromosome
• Accession: NZ_CP051483
• Organism: Staphylococcus aureus strain NGA66a

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: HGO94_RS11595
• Protein ID: WP_000482647.1
• Coordinates: 2367115..2367222 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2367239..2367299 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO94_RS11570	2362487..2362960	+	474	WP_000456497.1	GyrI-like domain-containing protein	-
HGO94_RS11575	2363083..2364294	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HGO94_RS11580	2364476..2365135	-	660	WP_000831301.1	membrane protein	-
HGO94_RS11585	2365195..2366337	-	1143	WP_249741382.1	glycerate kinase	-
HGO94_RS11590	2366595..2366981	+	387	WP_000779360.1	flippase GtxA	-
HGO94_RS11595	2367115..2367222	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2367239..2367299	-	61	-	-	Antitoxin
HGO94_RS11600	2367906..2369669	+	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
HGO94_RS11605	2369694..2371427	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
HGO94_RS11610	2371658..2371825	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T154259 WP_000482647.1 NZ_CP051483:2367115-2367222 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T154259 NZ_CP067426:c1229659-1229252 [Escherichia coli O22:H8]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT154259 NZ_CP051483:c2367299-2367239 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin