Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2335586..2336109 | Replicon | chromosome |
Accession | NZ_CP051483 | ||
Organism | Staphylococcus aureus strain NGA66a |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | X5DYX7 |
Locus tag | HGO94_RS11455 | Protein ID | WP_000074048.1 |
Coordinates | 2335843..2336109 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | W8TQT5 |
Locus tag | HGO94_RS11450 | Protein ID | WP_000587616.1 |
Coordinates | 2335586..2335843 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HGO94_RS11435 (2332082) | 2332082..2332831 | - | 750 | WP_000072445.1 | CPBP family lipoprotein N-acylation protein LnsB | - |
HGO94_RS11440 (2333027) | 2333027..2334604 | + | 1578 | WP_000143496.1 | FMN-binding glutamate synthase family protein | - |
HGO94_RS11445 (2334772) | 2334772..2335227 | - | 456 | WP_000732082.1 | DUF1307 domain-containing protein | - |
HGO94_RS11450 (2335586) | 2335586..2335843 | + | 258 | WP_000587616.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HGO94_RS11455 (2335843) | 2335843..2336109 | + | 267 | WP_000074048.1 | Txe/YoeB family addiction module toxin | Toxin |
HGO94_RS11460 (2336465) | 2336465..2337541 | + | 1077 | WP_001076671.1 | M42 family metallopeptidase | - |
HGO94_RS11465 (2337789) | 2337789..2338451 | + | 663 | WP_000923523.1 | ATP-binding cassette domain-containing protein | - |
HGO94_RS11470 (2338444) | 2338444..2339220 | + | 777 | WP_000072145.1 | iron export ABC transporter permease subunit FetB | - |
HGO94_RS11475 (2339616) | 2339616..2340803 | + | 1188 | WP_054193107.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10648.23 Da Isoelectric Point: 10.1384
>T154258 WP_000074048.1 NZ_CP051483:2335843-2336109 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
Download Length: 267 bp
>T154258 NZ_CP067426:c1093319-1092984 [Escherichia coli O22:H8]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9774.73 Da Isoelectric Point: 4.1353
>AT154258 WP_000587616.1 NZ_CP051483:2335586-2335843 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
Download Length: 258 bp
>AT154258 NZ_CP067426:c1093567-1093319 [Escherichia coli O22:H8]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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