Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2335586..2336109 Replicon chromosome
Accession NZ_CP051483
Organism Staphylococcus aureus strain NGA66a

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag HGO94_RS11455 Protein ID WP_000074048.1
Coordinates 2335843..2336109 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag HGO94_RS11450 Protein ID WP_000587616.1
Coordinates 2335586..2335843 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO94_RS11435 (2332082) 2332082..2332831 - 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -
HGO94_RS11440 (2333027) 2333027..2334604 + 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
HGO94_RS11445 (2334772) 2334772..2335227 - 456 WP_000732082.1 DUF1307 domain-containing protein -
HGO94_RS11450 (2335586) 2335586..2335843 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGO94_RS11455 (2335843) 2335843..2336109 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
HGO94_RS11460 (2336465) 2336465..2337541 + 1077 WP_001076671.1 M42 family metallopeptidase -
HGO94_RS11465 (2337789) 2337789..2338451 + 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
HGO94_RS11470 (2338444) 2338444..2339220 + 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
HGO94_RS11475 (2339616) 2339616..2340803 + 1188 WP_054193107.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T154258 WP_000074048.1 NZ_CP051483:2335843-2336109 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T154258 NZ_CP067426:c1093319-1092984 [Escherichia coli O22:H8]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT154258 WP_000587616.1 NZ_CP051483:2335586-2335843 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT154258 NZ_CP067426:c1093567-1093319 [Escherichia coli O22:H8]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References