Detailed information of TA system TA154245

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2687248..2687510
• Replicon: chromosome
• Accession: NZ_CP051482
• Organism: Staphylococcus aureus strain NGA104a

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HGO93_RS13230
• Protein ID: WP_001802298.1
• Coordinates: 2687248..2687352 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2687347..2687510 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO93_RS13215	2684044..2684826	+	783	WP_000908178.1	ABC transporter ATP-binding protein	-
HGO93_RS13220	2684894..2685751	+	858	WP_000370917.1	HAD family hydrolase	-
HGO93_RS13225	2686410..2686568	-	159	WP_001792784.1	hypothetical protein	-
HGO93_RS13230	2687248..2687352	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2687347..2687510	-	164	-	-	Antitoxin
HGO93_RS13240	2687785..2688876	-	1092	WP_000495683.1	hypothetical protein	-
HGO93_RS13245	2689142..2690122	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
HGO93_RS13250	2690124..2690444	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HGO93_RS13255	2690596..2691261	+	666	WP_001024105.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T154245 WP_001802298.1 NZ_CP051482:2687248-2687352 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T154245 NZ_CP067420:c779502-779248 [Skermanella sp. TT6]
ATGAACAACGCGCACCGCAAAACACTGGCCAGCATCTTTGACCGACCGACCAGAGCGGATATCCGCTGGACGGCCATTGA
GGCGCCTGTACTGGCTCTGGGCGGCAAAGTGGTTGAGCGGGCTGGCAGCCGGGTGTTGTTCGAAGTGAGCGGCATAACCG
CGATCTTTCATCGACCGCACCCGCAACCTACCACGAAGAAGGGTGCGGTGGATGCGGTCAGGCAGTTCTTGAGCAACGCT
GGAGTGGAGCCATGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT154245 NZ_CP051482:c2687510-2687347 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin