Detailed information of TA system TA154244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2433979..2434496
• Replicon: chromosome
• Accession: NZ_CP051482
• Organism: Staphylococcus aureus strain NGA104a

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: HGO93_RS11915
• Protein ID: WP_000113262.1
• Coordinates: 2434230..2434496 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: HGO93_RS11910
• Protein ID: WP_000584499.1
• Coordinates: 2433979..2434230 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO93_RS11880 (2429677)	2429677..2430396	+	720	WP_000479576.1	amino acid ABC transporter permease	-
HGO93_RS11885 (2430393)	2430393..2431124	+	732	WP_000615458.1	ATP-binding cassette domain-containing protein	-
HGO93_RS11890 (2431221)	2431221..2432471	-	1251	WP_001012222.1	FemA/FemB family glycyltransferase FmhA	-
HGO93_RS11895 (2432726)	2432726..2433088	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
HGO93_RS11900 (2433107)	2433107..2433706	+	600	WP_000162810.1	DsbA family protein	-
HGO93_RS11905 (2433734)	2433734..2433814	+	81	WP_223197974.1	hypothetical protein	-
HGO93_RS11910 (2433979)	2433979..2434230	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HGO93_RS11915 (2434230)	2434230..2434496	+	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
HGO93_RS11920 (2434531)	2434531..2434602	+	72	WP_223200558.1	hypothetical protein	-
HGO93_RS11925 (2434790)	2434790..2436340	+	1551	WP_054193111.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
HGO93_RS11930 (2436526)	2436526..2436993	+	468	WP_000153344.1	SRPBCC domain-containing protein	-
HGO93_RS11935 (2437077)	2437077..2437259	+	183	WP_000230294.1	hypothetical protein	-
HGO93_RS11940 (2437476)	2437476..2438300	+	825	WP_000572040.1	formate/nitrite transporter family protein	-
HGO93_RS11945 (2438544)	2438544..2439071	+	528	WP_000973468.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T154244 WP_000113262.1 NZ_CP051482:2434230-2434496 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T154244 NZ_CP067419:12830-13117 [Aeromonas media]
ATGACCTTTGAGCTTGAGTTCGATCCACGAGCGTGGAAGGAGTGGAAGAAGCTGGGTGATACCGTGCGCCAGCAGTTCAA
GAAGAAGCTGGCAGAGGTACTGGAGCGACCAAGGGTCGAGGCCAACCGCCTGCATGGGCTGCCGGATTGCTACAAGATCA
AGCTGCGTGGGGCGGGGTATCGGTTGGTGTACCAGGTACAGGATGATCGGGTGCTGGTATTCGTGGTCGCGGTGGGGAAA
CGAGAGCGGGAGCAGGTGTATTTGGACGCTGGCTCGAGGCTGGAATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT154244 WP_000584499.1 NZ_CP051482:2433979-2434230 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT154244 NZ_CP067419:12598-12840 [Aeromonas media]
ATGGGCACGATCAATCTTCGCATCGACGACGATCTTAAGACTCGTTCGTATGCTGTCCTTGAAAAACTGGGCGTAACCCC
CTCGGAGCTGCTGCGGCAAACCCTGGAGTATGTTGCTTCCCAGGAGCGGTTGCCGTTTCGGACGACCGTGGTAACGGAGG
ATGAGGAGGCGCTGCTTGCCCTCGTTCGTGAGCGGCTGGCCAGCCCCCAGAAAGGGATCAGGGTGTCGCTGGATGACCTT
TGA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60