Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2377302..2377825 Replicon chromosome
Accession NZ_CP051482
Organism Staphylococcus aureus strain NGA104a

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag HGO93_RS11640 Protein ID WP_000074048.1
Coordinates 2377559..2377825 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag HGO93_RS11635 Protein ID WP_000587616.1
Coordinates 2377302..2377559 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO93_RS11620 (2373798) 2373798..2374547 - 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -
HGO93_RS11625 (2374743) 2374743..2376320 + 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
HGO93_RS11630 (2376488) 2376488..2376943 - 456 WP_000732082.1 DUF1307 domain-containing protein -
HGO93_RS11635 (2377302) 2377302..2377559 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGO93_RS11640 (2377559) 2377559..2377825 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
HGO93_RS11645 (2378181) 2378181..2379257 + 1077 WP_001076671.1 M42 family metallopeptidase -
HGO93_RS11650 (2379505) 2379505..2380167 + 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
HGO93_RS11655 (2380160) 2380160..2380936 + 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
HGO93_RS11660 (2381332) 2381332..2382519 + 1188 WP_054193107.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T154241 WP_000074048.1 NZ_CP051482:2377559-2377825 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T154241 NZ_CP067417:c2830411-2830124 [Aeromonas media]
ATGACCTTTGAGCTTGAGTTCGATCCACGAGCGTGGAAGGAGTGGAAGAAGCTGGGTGATACCGTGCGCCAGCAGTTCAA
GAAGAAGCTGGCAGAGGTACTGGAGCGACCAAGGGTCGAGGCCAACCGCCTGCATGGGCTGCCGGATTGCTACAAGATCA
AGCTGCGTGGGGCGGGGTATCGGTTGGTGTACCAGGTACAGGATGATCGGGTGCTGGTATTCGTGGTCGCGGTGGGGAAA
CGAGAGCGGGAGCAGGTGTATTTGGACGCTGGCTCGAGGCTGGAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT154241 WP_000587616.1 NZ_CP051482:2377302-2377559 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT154241 NZ_CP067417:c2830643-2830401 [Aeromonas media]
ATGGGCACGATCAATCTTCGCATCGACGACGATCTTAAGACTCGTTCGTATGCTGTCCTTGAAAAACTGGGCGTAACCCC
CTCGGAGCTGCTGCGGCAAACCCTGGAGTATGTTGCTTCCCAGGAGCGGTTGCCGTTTCGGACGACCGTGGTAACGGAGG
ATGAGGAGGCGCTGCTTGCCCTCGTTCGTGAGCGGCTGGCCAGCCCCCAGAAAGGGATCAGGGTGTCGCTGGATGACCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References