Detailed information of TA system TA154238

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 178901..179083
• Replicon: chromosome
• Accession: NZ_CP051482
• Organism: Staphylococcus aureus strain NGA104a

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HGO93_RS01080
• Protein ID: WP_001801861.1
• Coordinates: 178988..179083 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	178901..178960 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO93_RS01065	178039..178416	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
HGO93_RS01070	178610..178786	+	177	Protein_174	transposase	-
HGO93_RS01075	178764..178865	-	102	WP_001791893.1	hypothetical protein	-
-	178901..178960	+	60	-	-	Antitoxin
HGO93_RS01080	178988..179083	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
HGO93_RS01085	179286..179429	+	144	WP_001549059.1	transposase	-
HGO93_RS01090	180033..180416	+	384	WP_000070811.1	hypothetical protein	-
HGO93_RS01095	180427..180603	+	177	WP_000375477.1	hypothetical protein	-
HGO93_RS01100	180621..180791	+	171	WP_169301139.1	hypothetical protein	-
HGO93_RS01105	180906..181534	+	629	Protein_181	ImmA/IrrE family metallo-endopeptidase	-
HGO93_RS01110	181732..182304	-	573	WP_000414202.1	hypothetical protein	-
HGO93_RS01115	182405..182746	-	342	WP_000627541.1	DUF3969 family protein	-
HGO93_RS01120	182787..183413	-	627	WP_000669017.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	120516..202780	82264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-109)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T154238 WP_001801861.1 NZ_CP051482:c179083-178988 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T154238 NZ_CP067416:860960-861331 [Mammaliicoccus sciuri]
ATGAGAAGAGGAGATGTATATCTCGCAGATCTTTCACCAGTTACAGGTTCTGAACAAGGGGGAACAAGACCAGTCGTTAT
TATCCAGAATGATACAGGTAATCGATACAGCCCGACTGTGATTGTTGCAGCAATTACTGGTAAGATAAATAAAGCCAAAA
TTCCCACTCATGTAGAAATTGAGGCAGCGAAATATAAATTAGACAGAGATTCCGTAATTTTGCTTGAACAAATCAGAACA
ATTGATAAAAAACGCTTAAAAGAAAAATTAACATATTTATCTGATGCAAAGATGAAAGAGGTTGATATCGCTATTGCCAT
CAGCCTCAATCTAACTTTGCAACAAAAATTTGATACATTAGGTAATACATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT154238 NZ_CP051482:178901-178960 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin