Detailed information of TA system TA154234

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19310..19648
• Replicon: chromosome
• Accession: NZ_CP051482
• Organism: Staphylococcus aureus strain NGA104a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HGO93_RS00100
• Protein ID: WP_011447039.1
• Coordinates: 19310..19486 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19474..19648 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO93_RS00080	14545..18330	+	3786	WP_000582165.1	phage tail spike protein	-
HGO93_RS00085	18320..18472	+	153	WP_001153681.1	hypothetical protein	-
HGO93_RS00090	18519..18806	+	288	WP_001040261.1	hypothetical protein	-
HGO93_RS00095	18864..19160	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
HGO93_RS00100	19310..19486	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19474..19648	-	175	-	-	Antitoxin
HGO93_RS00110	19698..19952	+	255	WP_000611512.1	phage holin	-
HGO93_RS00115	19964..20719	+	756	WP_000861038.1	CHAP domain-containing protein	-
HGO93_RS00120	20910..21401	+	492	WP_000919350.1	staphylokinase	-
HGO93_RS00125	22051..22386	+	336	Protein_24	SH3 domain-containing protein	-
HGO93_RS00130	22481..22930	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HGO93_RS00135	23615..23965	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
HGO93_RS00140	24018..24278	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	51..23965	23914

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T154234 WP_011447039.1 NZ_CP051482:19310-19486 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T154234 NZ_CP067413:c2396345-2395872 [Raoultella ornithinolytica]
ATGATTTTCTATCGTCTGGTTACCGGCCGTTACGCCAGCGAAGCCTGGACGGGAAGCGGGGCCAACCAGTACGGCGGGCG
CTGGAATCACCAGGGACACCCGGCGGTCTATGTGTCCACTTCCATTGCCCTGGCGTCACTGGAGATCCTGGTTCACGTCA
AAAATGAGGCAATCCTCAACCAGTATCAGCTGTATAGTATCGAGATACCGGACAGCGAAGTGGAATCCCTCGATAAACAG
TGGTTACCGGATAACTGGCAAGAAAATCCGATGCCCGTTTCCACAATGGATCTGGGCACCGGCTGGCTACAGTCGGGCAG
CGGTCTGGCGCTGATGCTTCCCTCCTGCATTATTCCCTATGAAAACAACGCCATTTTAAACCCGCTGCATCCCGCGTTCA
GCGAGGCCCTGGCCTCCGTGCGTCAGTATCCCTTTACCTTTGATCCCCGCCTCGCACGCTCCACGCCCCTCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT154234 NZ_CP051482:c19648-19474 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin