Detailed information of TA system TA154229

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2640583..2640862
• Replicon: chromosome
• Accession: NZ_CP051479
• Organism: Staphylococcus aureus strain NGA76

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HF085_RS13005
• Protein ID: WP_001802298.1
• Coordinates: 2640583..2640687 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2640683..2640862 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF085_RS12975	2635967..2636749	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
HF085_RS12980	2636817..2637674	+	858	WP_000370924.1	HAD family hydrolase	-
HF085_RS12990	2638379..2638471	-	93	WP_001790138.1	hypothetical protein	-
HF085_RS12995	2638760..2639896	+	1137	WP_000115564.1	SAP domain-containing protein	-
HF085_RS13000	2639939..2640422	+	484	Protein_2525	recombinase family protein	-
HF085_RS13005	2640583..2640687	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2640683..2640862	-	180	-	-	Antitoxin
HF085_RS13015	2641130..2642221	-	1092	WP_000495683.1	hypothetical protein	-
HF085_RS13020	2642487..2643467	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
HF085_RS13025	2643469..2643789	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HF085_RS13030	2643941..2644606	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T154229 WP_001802298.1 NZ_CP051479:2640583-2640687 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T154229 NZ_CP067412:5636650-5636970 [Pseudomonas sp. HS6]
ATGATTTTTGTTGAGACTCGGATCTTTACTCGTCGAGTAAAAGAGCTGCTGGACGATCACACGTATGCCGCTTTTCAGAA
GCAACTGGTTGTAAGTCCTTCGATTGGCGATGTAATTGAAGGCACAGGCGGGATCCGCAAAACCCGAATCGCAGCGAAAG
GACACGGCAAGCGAGGCGGAGCACGGGTGATCTACTACCACTTCGTTTCGGCGTCACAAATCGGGTTATTGATGATCTAC
CCTAAAAATGAACAACACGATCTGTCCAGCGATGAGCGTAAAGCACTCAAGGTCTTGATCGAAAAATGGAGATGCCCATG
A

Antitoxin

Nucleotide

• Length: 180 bp

>AT154229 NZ_CP051479:c2640862-2640683 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin