Detailed information of TA system TA154225

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2355479..2355663
• Replicon: chromosome
• Accession: NZ_CP051479
• Organism: Staphylococcus aureus strain NGA76

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: HF085_RS11520
• Protein ID: WP_000482652.1
• Coordinates: 2355479..2355586 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2355603..2355663 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF085_RS11495	2350841..2351314	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
HF085_RS11500	2351437..2352648	-	1212	WP_001191922.1	multidrug effflux MFS transporter	-
HF085_RS11505	2352830..2353489	-	660	WP_000831298.1	membrane protein	-
HF085_RS11510	2353549..2354691	-	1143	WP_001176863.1	glycerate kinase	-
HF085_RS11515	2354959..2355345	+	387	WP_000779357.1	flippase GtxA	-
HF085_RS11520	2355479..2355586	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2355603..2355663	-	61	-	-	Antitoxin
HF085_RS11525	2356289..2358052	+	1764	WP_001064837.1	ABC transporter ATP-binding protein	-
HF085_RS11530	2358077..2359810	+	1734	Protein_2241	ABC transporter ATP-binding protein	-
HF085_RS11535	2360041..2360208	+	168	WP_001789205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T154225 WP_000482652.1 NZ_CP051479:2355479-2355586 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T154225 NZ_CP067412:c3258052-3257756 [Pseudomonas sp. HS6]
ATGCCCACAGATGTACAGGATGTTTTTGGTCACGCACTGGATTTGGCCCAAAGCGGTCTCAAACATCCAGATGCAAAACC
TCTGAAGGGGTTTGGAGGCGCGGGTGTCCTCGAGTTGATTGAGGACTTTGATACGAATACCTACCGCGCCGTTTACACGG
TCCGTTTTGGCAATGCGATTTACGTCTTGCATTGTTTTCAGAAGAAGTCGACCACCGGTATAAAAACCGCGCAGTGCGAT
GTCGATCTGATCCGAAAGAGACTTCAAGCCGCTCAGGATCACGCGAAAGGAACATAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT154225 NZ_CP051479:c2355663-2355603 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin