Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2323581..2324104 Replicon chromosome
Accession NZ_CP051479
Organism Staphylococcus aureus strain NGA76

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag HF085_RS11380 Protein ID WP_000074045.1
Coordinates 2323838..2324104 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag HF085_RS11375 Protein ID WP_000587619.1
Coordinates 2323581..2323838 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF085_RS11355 (2318659) 2318659..2319852 + 1194 WP_000675407.1 MFS transporter -
HF085_RS11360 (2320076) 2320076..2320825 - 750 WP_000072465.1 CPBP family lipoprotein N-acylation protein LnsB -
HF085_RS11365 (2321021) 2321021..2322598 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
HF085_RS11370 (2322766) 2322766..2323221 - 456 WP_000732079.1 DUF1307 domain-containing protein -
HF085_RS11375 (2323581) 2323581..2323838 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HF085_RS11380 (2323838) 2323838..2324104 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
HF085_RS11385 (2324459) 2324459..2325535 + 1077 WP_001076671.1 M42 family metallopeptidase -
HF085_RS11390 (2325783) 2325783..2326445 + 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
HF085_RS11395 (2326438) 2326438..2327214 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
HF085_RS11400 (2327610) 2327610..2328797 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T154224 WP_000074045.1 NZ_CP051479:2323838-2324104 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T154224 NZ_CP067412:941589-941870 [Pseudomonas sp. HS6]
ATGACCTATGAGCTGGAGTTCTCGGAGAAAGCCTGGAAAGAATGGAAAAAGCTTGATGCGAATCTCAAGGAGCAATTAAA
GAAGAAACTTCAGCAGCGGCTTGAGAATCCGCATGTTCCAGCCGACCGGCTCAGAGGACTGGGAAGCGCCTACAAGATCA
AGCTTCGAAATGTCGGGTATCGAATGGTCTATCGGGTCAAGGACGAGGTGCTGGTCGTGACAGTAATAGCCATTGGTAAA
AGGGAGGGCGGAGACGTATACAGAGTTGCTACGGAGCGTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT154224 WP_000587619.1 NZ_CP051479:2323581-2323838 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT154224 NZ_CP067412:941351-941599 [Pseudomonas sp. HS6]
ATGACACATATCGTCCTTTCCCAAGTCGTAGCGAGCATTTCCGAACTGAAAAAAAATCCCATGGGTACTGTCGCAGCAGG
CGGCGGTGATTCCGTTGCAATTCTCAACCGCAATGAGCCGGCCTTTTATTGCGTCCCGGCAAAAGCCTATGAGGCGCTGA
TGAATCGCCTTGAGGATCTGGAGTTGATTGCTCTGTGCAAGGAACGGGAAAATGATCCCACCATAAAGGTCTCGATAGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References